Journal article
Gene therapy for stroke: 2006 overview
Current hypertension reports, Vol.9(1), pp.19-24
03/2007
DOI: 10.1007/s11906-007-0005-7
PMID: 17362667
Abstract
Gene therapy is a promising approach for treatment of stroke and other cerebrovascular diseases, although it may take many years to realize. Gene therapy could occur prior to a stroke (eg, to stabilize atherosclerotic plaques) and/or following a stroke (eg, to prevent vasospasm after subarachnoid hemorrhage or reduce injury to neurons by ischemic insult). We have transferred the gene coding for vasoactive calcitonin gene-related peptide via cerebrospinal fluid, and demonstrated attenuation of vasospasm after SAH. Transfer of neuroprotective genes or small interfering RNA for neurotoxic genes has good potential for ischemic stroke. In this brief report, we review recent developments in experimental gene therapy for stroke. Fundamental advances, including development of safer, more specific gene transfer vectors, are discussed.
Details
- Title: Subtitle
- Gene therapy for stroke: 2006 overview
- Creators
- Yi Chu - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USAJordan D MillerDonald D Heistad
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.9(1), pp.19-24
- Publisher
- United States
- DOI
- 10.1007/s11906-007-0005-7
- PMID
- 17362667
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Grant note
- NS 24621 / NINDS NIH HHS HL 62984 / NHLBI NIH HHS HL 16066 / NHLBI NIH HHS
- Language
- English
- Date published
- 03/2007
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040249302771
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