Journal article
Gene therapy of hypertensive vascular injury
Current hypertension reports, Vol.2(1), pp.92-97
02/2000
DOI: 10.1007/s11906-000-0065-4
PMID: 10981134
Abstract
Hypertension and vascular injury usually require prolonged treatment, and compliance is a key to efficacy for pharmacologically-based antihypertensive therapy. Gene therapy has the potential to be long lasting, with few side effects. Recent studies have provided promising results, in which hypertension can be treated by either augmentation of vasodilation or inhibition of vasoconstriction through gene transfer in experimental models. Gene transfer is also becoming useful for the study of mechanisms of physiologic and pathophysiologic conditions, including hypertension. In this mini-review, we summarize some recent studies in this area of research, and suggest some areas where progress is needed t advance the research toward gene therapy.
Details
- Title: Subtitle
- Gene therapy of hypertensive vascular injury
- Creators
- Yi Chu - Cardiovascular Center, Department of Internal Medicine University of Iowa College of Medicine 52242 Iowa City Iowa USAFrank Faraci - Cardiovascular Center, Departments of Internal Medicine and Pharmacology University of Iowa College of Medicine 52242 Iowa City Iowa USADonald Heistad - Cardiovascular Center, Departments of Internal Medicine and Pharmacology VA Medical Center, University of Iowa College of Medicine 52242 Iowa City Iowa USA
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.2(1), pp.92-97
- Publisher
- Current Medicine Group; Philadelphia
- DOI
- 10.1007/s11906-000-0065-4
- PMID
- 10981134
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Language
- English
- Date published
- 02/2000
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040498702771
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