Journal article
Gene/environment causes of cleft lip and/or palate
Clinical genetics, Vol.61(4), pp.248-256
04/2002
DOI: 10.1034/j.1399-0004.2002.610402.x
PMID: 12030886
Abstract
Craniofacial anomalies, and in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. A wide range of studies in developmental biology has contributed to a better knowledge of how both genes and environmental exposures impact head organogenesis. Specific causes have now been identified for some forms of cleft lip and palate, and we are at the beginning of a time in which the common nonsyndromic forms may also have specific etiologies identified. Mouse models have an especially important role in disclosing cleft etiologies and providing models for environmental cotriggers or interventions. An overview of the gene-environment contributions to nonsyndromic forms of clefting and their implications for developmental biology and clinical counseling is presented.
Details
- Title: Subtitle
- Gene/environment causes of cleft lip and/or palate
- Creators
- J C Murray - Department of Pediatrics, University of Iowa, Iowa City 52242, USA
- Resource Type
- Journal article
- Publication Details
- Clinical genetics, Vol.61(4), pp.248-256
- DOI
- 10.1034/j.1399-0004.2002.610402.x
- PMID
- 12030886
- NLM abbreviation
- Clin Genet
- ISSN
- 0009-9163
- eISSN
- 1399-0004
- Publisher
- Denmark
- Grant note
- ES10876 / NIEHS NIH HHS DE08559 / NIDCR NIH HHS DE13076 / NIDCR NIH HHS U50/CCU713238 / ODCDC CDC HHS
- Language
- English
- Date published
- 04/2002
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025674002771
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