Journal article
Generating Better Medicines for Cancer
ACS macro letters, Vol.2(5), pp.393-397
04/24/2013
DOI: 10.1021/mz400116a
PMCID: PMC3680140
PMID: 23772351
Abstract
The complexity of tumor biology warrants tailored drug delivery for overcoming the major challenges faced by cancer therapies. The versatility of the PRINT
®
(Particle Replication In Non-wetting Templates) process has enabled the preparation of shape- and size-specific particles with a wide range of chemical compositions and therapeutic cargos. Different particle matrices and drugs may be combined in a plug-and-play approach, such that physico-chemical characteristics of delivery vectors may be optimized for biocompatibility, cargo stability and release, circulation half-life, and efficacy. Thus, the engineering of particles for cancer therapy with specific biophysical behaviors and cellular responses has been demonstrated via the PRINT process.
Details
- Title: Subtitle
- Generating Better Medicines for Cancer
- Creators
- Stuart S. Dunn - North Carolina State UniversityJames D. Byrne - North Carolina State UniversityJillian L. Perry - North Carolina State UniversityKai Chen - North Carolina State UniversityJoseph M. DeSimone - North Carolina State University
- Resource Type
- Journal article
- Publication Details
- ACS macro letters, Vol.2(5), pp.393-397
- DOI
- 10.1021/mz400116a
- PMID
- 23772351
- PMCID
- PMC3680140
- NLM abbreviation
- ACS Macro Lett
- ISSN
- 2161-1653
- eISSN
- 2161-1653
- Grant note
- U54 CA151652 || CA / National Cancer Institute : NCI R01 EB009565 || EB / National Institute of Biomedical Imaging and Bioengineering : NIBIB DP1 OD006432 || OD / Office of the Director : NIH
- Language
- English
- Date published
- 04/24/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiation Oncology
- Record Identifier
- 9984274857402771
Metrics
13 Record Views