Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Luda Diatchenko; Robert L Strausberg; Kate Marusina; Elise A Feingold; Andrew A Farmer; Lynette H Grouse; Gerald M Rubin; Jeffery G Derge; Ling Hong; Francis S Collins; Mark Stapleton; Lukas Wagner; M Bento Soares; Richard D Klausner; Maria F Bonaldo; Carolyn M Shenmen; Tom L Casavant; Gregory D Schuler; Todd E Scheetz; Stephen F Altschul; Michael J Brownstein; Barry Zeeberg; Ted B Usdin; Kenneth H Buetow; Shiraki Toshiyuki; Carl F Schaefer; Piero Carninci; Narayan K Bhat; Christa Prange; Ralph F Hopkins; Sam S Raha; Heather Jordan; Naomi A Loquellano; Troy Moore; Garrick J Peters; Steve I Max; Rick D Abramson; Jun Wang; Sara J Mullahy; Florence Hsieh; Stephanie A Bosak; Paul J McEwan; Kevin J McKernan; Joel A Malek; Preethi H Gunaratne; Stephen Richards; Kim C Worley; Sarah Hale; Angela M Garcia; Laura J Gay; Stephen W Hulyk; Debbie K Villalon; Donna M Muzny; Erica J Sodergren; Xiuhua Lu; Richard A Gibbs; Jessica Fahey; Erin Helton; Mark Ketteman; Anuradha Madan; Stephanie Rodrigues; Amy Sanchez; Michelle Whiting; Anup Madan; Alice C Young; Yuriy Shevchenko; Gerard G Bouffard; Robert W Blakesley; Jeffrey W Touchman; Eric D Green; Mark C Dickson; Alex C Rodriguez; Jane Grimwood; Jeremy Schmutz; Richard M Myers; Yaron S N Butterfield; Martin I Krzywinski; Ursula Skalska; Duane E Smailus; Angelique Schnerch; Jacqueline E Schein; Steven J M Jones; Marco A Marra; Mammalian Gene Collection Program Team

doi:10.1073/pnas.242603899

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Journal article

Open access

Peer reviewed

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Luda Diatchenko, Robert L Strausberg, Kate Marusina, Elise A Feingold, Andrew A Farmer, Lynette H Grouse, Gerald M Rubin, Jeffery G Derge, Ling Hong, Francis S Collins, …

Proceedings of the National Academy of Sciences - PNAS, Vol.99(26), pp.16899-16903

12/24/2002

DOI: 10.1073/pnas.242603899

PMCID: PMC139241

PMID: 12477932

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Abstract

The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones for an additional 7,800 human and 3,500 mouse genes also have been identified. All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov).

Algorithms

DNA, Complementary - analysis

Animals

Gene Library

Humans

Open Reading Frames

Mice

DNA, Complementary - chemistry

Sequence Analysis, DNA

Details

Title: Subtitle: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Creators: Luda Diatchenko
Robert L Strausberg - National Cancer Institute, Bethessda, MD 20892-2580, USA. rls@nih.gov
Kate Marusina
Elise A Feingold
Andrew A Farmer
Lynette H Grouse
Gerald M Rubin
Jeffery G Derge
Ling Hong - University of California, Berkeley
Francis S Collins
Mark Stapleton
Lukas Wagner
M Bento Soares
Richard D Klausner
Maria F Bonaldo
Carolyn M Shenmen
Tom L Casavant
Gregory D Schuler
Todd E Scheetz
Stephen F Altschul
Michael J Brownstein
Barry Zeeberg
Ted B Usdin
Kenneth H Buetow
Shiraki Toshiyuki
Carl F Schaefer
Piero Carninci
Narayan K Bhat
Christa Prange
Ralph F Hopkins
Sam S Raha
Heather Jordan
Naomi A Loquellano
Troy Moore
Garrick J Peters
Steve I Max
Rick D Abramson
Jun Wang
Sara J Mullahy
Florence Hsieh
Stephanie A Bosak
Paul J McEwan
Kevin J McKernan
Joel A Malek
Preethi H Gunaratne
Stephen Richards
Kim C Worley
Sarah Hale
Angela M Garcia
Laura J Gay
Stephen W Hulyk
Debbie K Villalon
Donna M Muzny
Erica J Sodergren
Xiuhua Lu
Richard A Gibbs
Jessica Fahey
Erin Helton
Mark Ketteman
Anuradha Madan
Stephanie Rodrigues
Amy Sanchez
Michelle Whiting
Anup Madan
Alice C Young
Yuriy Shevchenko
Gerard G Bouffard
Robert W Blakesley
Jeffrey W Touchman
Eric D Green
Mark C Dickson
Alex C Rodriguez
Jane Grimwood
Jeremy Schmutz
Richard M Myers
Yaron S N Butterfield
Martin I Krzywinski
Ursula Skalska
Duane E Smailus
Angelique Schnerch
Jacqueline E Schein
Steven J M Jones
Marco A Marra
Mammalian Gene Collection Program Team
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.99(26), pp.16899-16903
DOI: 10.1073/pnas.242603899
PMID: 12477932
PMCID: PMC139241
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: United States
Language: English
Date published: 12/24/2002
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Ophthalmology and Visual Sciences
Record Identifier: 9983979964702771

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