Journal article
Generation-based study of airway remodeling in smokers with normal-looking CT with normalization to control inter-subject variability
European journal of radiology, Vol.138, pp.109657-109657
05/2021
DOI: 10.1016/j.ejrad.2021.109657
PMID: 33773402
Abstract
With the help of quantitative computed tomography (QCT), it is possible to identify smoking-associated airway remodeling. However, there is currently little information on whether QCT-based airway metrics are sensitive to early airway wall remodeling in subclinical phases of smoking-associated airway disease. This study aimed to evaluate a predictive model that normalized airway parameters and investigate structural airway alterations in smokers with normal-looking CT using the normalization scheme.
In this retrospective analysis, 222 non-smokers (male 97, female 125) and 69 smokers (male 66, female 3) from January 2014 to December 2016 were included, and airway parameters were quantitatively analyzed. To control inter-subject variability, multiple linear regressions of tracheal wall thickness (WT), diameter (D), and luminal area (LA) were performed, adjusted for age, sex, and height. Using this normalization scheme, airway parameters with matched generation were compared between smokers and non-smokers.
Using the normalization scheme, it was possible to assess generation-based structural alterations of the airways in subclinical smokers. Smokers showed diffuse luminal narrowing of airways for most generations (P < 0.05, except 3rd generation), no change in wall thickness of the proximal bronchi (1st-3rd generation), and a thinning of distal airways (P <0.05, ≥4th generation).
QCT assessment for subclinical smokers can help identify minimal structural changes in airways induced by smoking.
Details
- Title: Subtitle
- Generation-based study of airway remodeling in smokers with normal-looking CT with normalization to control inter-subject variability
- Creators
- Kum Ju Chae - Jeonbuk National UniversityGong Yong Jin - Jeonbuk National UniversityJiwoong Choi - University of KansasChang Hyun Lee - Seoul National University HospitalSanghun Choi - Kyungpook National UniversityHyemi Choi - Jeonbuk National UniversityJeongjae Park - Wonkwang UniversityChing-Long Lin - University of IowaEric A Hoffman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- European journal of radiology, Vol.138, pp.109657-109657
- DOI
- 10.1016/j.ejrad.2021.109657
- PMID
- 33773402
- NLM abbreviation
- Eur J Radiol
- ISSN
- 0720-048X
- eISSN
- 1872-7727
- Publisher
- Elsevier B.V
- Grant note
- DOI: 10.13039/501100002864, name: Jeonbuk National University Hospital
- Language
- English
- Date published
- 05/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984196559602771
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