Journal article
Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs
CrystEngComm, Vol.19(22), pp.2983-2986
2017
DOI: 10.1039/C7CE00314E
Abstract
Cocrystals of the FDA-approved boron-containing API Tavaborole (AN2690) were obtained through solvent evaporation with coformers functionalized with 4-pyridyl groups. The components form three- and four-component supramolecular assemblies sustained by a combination of (B)OH⋯Npyr hydrogen bonds and C-H⋯F interactions, as demonstrated by single-crystal X-ray diffraction analysis. Three cocrystals are isostructural.
Details
- Title: Subtitle
- Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs
- Creators
- Gonzalo Campillo-AlvaradoColton A StaudtMelissa J BakLeonard R MacGillivray
- Resource Type
- Journal article
- Publication Details
- CrystEngComm, Vol.19(22), pp.2983-2986
- DOI
- 10.1039/C7CE00314E
- ISSN
- 1466-8033
- eISSN
- 1466-8033
- Grant note
- DOI: 10.13039/100000078, name: Division of Materials Research, award: 1408834
- Language
- English
- Date published
- 2017
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984216720402771
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