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Generative Artificial Intelligence through ChatGPT and Other Large Language Models in Ophthalmology: Clinical Applications and Challenges
Journal article   Open access   Peer reviewed

Generative Artificial Intelligence through ChatGPT and Other Large Language Models in Ophthalmology: Clinical Applications and Challenges

Ting Fang Tan, Arun James Thirunavukarasu, J Peter Campbell, Pearse A. Keane, Louis R. Pasquale, Michael D. Abramoff, Jayashree Kalpathy-Cramer, Flora Lum, Judy E. Kim, Sally L. Baxter, …
Ophthalmology science (Online), Vol.3(4), 100394
12/2023
DOI: 10.1016/j.xops.2023.100394
PMCID: PMC10598525
PMID: 37885755
url
https://doi.org/10.1016/j.xops.2023.100394View
Published (Version of record) Open Access

Abstract

The rapid progress of large language models (LLMs) driving generative artificial intelligence applications heralds the potential of opportunities in healthcare. We conducted a review up to April 2023 on Google Scholar, Embase, MEDLINE, and Scopus using the following terms: “large language models”, “generative artificial intelligence”, “ophthalmology”, “ChatGPT”, and “eye”, based on relevance to this review. From a clinical viewpoint specific to ophthalmologists, we explore from the different stakeholders’ perspectives— including patients, physicians, and policymakers— the potential LLM applications in education, research and clinical domains specific to ophthalmology. We also highlight the foreseeable challenges of LLM implementation into clinical practice, including the concerns of accuracy, interpretability, perpetuating bias, and data security. As LLMs continue to mature, it is essential for stakeholders to jointly establish standards for best practices to safeguard patient safety.
artificial intelligence chatbots ChatGPT large language models

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