Journal article
Genes and environment in neonatal intraventricular hemorrhage
Seminars in perinatology, Vol.39(8), pp.592-603
12/2015
DOI: 10.1053/j.semperi.2015.09.006
PMCID: PMC4668116
PMID: 26516117
Abstract
Emerging data suggest intraventricular hemorrhage (IVH) of the preterm neonate is a complex disorder with contributions from both the environment and the genome. Environmental analyses suggest factors mediating both cerebral blood flow and angiogenesis contribute to IVH, while candidate gene studies report variants in angiogenesis, inflammation, and vascular pathways. Gene-by-environment interactions demonstrate the interaction between the environment and the genome, and a non-replicated genome-wide association study suggests that both environmental and genetic factors contribute to the risk for severe IVH in very low-birth weight preterm neonates.
Details
- Title: Subtitle
- Genes and environment in neonatal intraventricular hemorrhage
- Creators
- Laura R Ment - Department of Pediatrics and Neurology, Yale University School of Medicine, 333 Cedar St, P.O. Box 208064, New Haven, CT 06520-8064Ulrika Ådén - Department of Women and Child health, Karolinska Institutet, Stockholm, SwedenCharles R Bauer - Department of Pediatrics, University of Miami-Leonard M. Miller School of Medicine, Miami, FloridaHenrietta S Bada - University of Kentucky, Lexington, KYWaldemar A Carlo - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, ALJeffrey R Kaiser - Department of Pediatrics, University of Arkansas, Little Rock, ARAiping Lin - Department of Pediatrics, Yale University School of Medicine, New Haven, CTCharles Michael Cotten - Department of Pediatrics, Duke University, Durham, NCJeffrey Murray - Department of Pediatrics, Anatomy and Cell Biology, Biology, Epidemiology, Preventive Medicine, University of Iowa, Iowa City, IAGrier Page - RTI International, Atlanta, GAMikko Hallman - Department of Pediatrics and Biocenter, University of Oulu and Oulu University Hospital, Oulu, FinlandRichard P Lifton - Department of Genetics, Yale University School of Medicine, New Haven, CTHeping Zhang - Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT
- Resource Type
- Journal article
- Publication Details
- Seminars in perinatology, Vol.39(8), pp.592-603
- DOI
- 10.1053/j.semperi.2015.09.006
- PMID
- 26516117
- PMCID
- PMC4668116
- NLM abbreviation
- Semin Perinatol
- ISSN
- 0146-0005
- eISSN
- 1558-075X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 12/2015
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025375602771
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