Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample

Fazil Aliev; Leah Wetherill; Laura Bierut; Kathleen K Bucholz; Howard Edenberg; Tatiana Foroud; Danielle M Dick; Collaborative Study on the Genetics of Alcoholism (COGA) Investigators

doi:10.15288/jsad.2015.76.38

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Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample

Journal article

Peer reviewed

Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample

Fazil Aliev, Leah Wetherill, Laura Bierut, Kathleen K Bucholz, Howard Edenberg, Tatiana Foroud, Danielle M Dick and Collaborative Study on the Genetics of Alcoholism (COGA) Investigators

Journal of studies on alcohol and drugs, Vol.76(1), pp.38-46

01/2015

DOI: 10.15288/jsad.2015.76.38

PMCID: PMC4263779

PMID: 25486392

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https://www.ncbi.nlm.nih.gov/pmc/articles/4263779View

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Abstract

The purpose of this study was to evaluate evidence for association with a panel of genes previously associated with alcohol-related traits in a new sample of adolescent and young adult individuals (N = 2,128; 51% female) collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). We tested for association with phenotypes related to externalizing behavior, including diagnostic symptom counts for disorders on the externalizing spectrum (alcohol dependence, conduct disorder, adult antisocial personality disorder, and illicit drug dependence), and related behavioral/personality traits (Achenbach Externalizing, NEO Extraversion, NEO Conscientiousness, Zuckerman's Sensation Seeking, and the Barratt Impulsivity Scale) based on the substantial literature suggesting that these behaviors may be alternate manifestations of a shared genetic liability. We tested for overall enrichment of the set of 215 genotyped single-nucleotide polymorphisms (SNPs) for each of the phenotypes. We conducted secondary analyses comparing results for sensation seeking with results for the other phenotypes. For all phenotypes, there was significant enrichment of association results (p < .05) compared with chance expectations. The greatest number of significant results was observed with the phenotype Sensation Seeking. Secondary analyses indicated that the number of SNPs yielding p < .05 with Sensation Seeking was significantly greater than that observed for each of the other phenotypes. We find evidence for enrichment of association results across a spectrum of externalizing phenotypes with a panel of candidate genes/SNPs selected based on previous suggestion of association with alcohol-related outcomes. In particular, we find significant enrichment of effects with sensation seeking, suggesting that this may be a particularly salient behavior associated with risk for alcohol-related problems.

Phenotype

Adolescent

Adult

Alcoholism - epidemiology

Alcoholism - genetics

Antisocial Personality Disorder - epidemiology

Antisocial Personality Disorder - genetics

Child

Conduct Disorder - epidemiology

Conduct Disorder - genetics

Female

Genotype

Humans

Impulsive Behavior

Male

Polymorphism, Single Nucleotide

Prospective Studies

Substance-Related Disorders - epidemiology

Substance-Related Disorders - genetics

Young Adult

Details

Title: Subtitle: Genes associated with alcohol outcomes show enrichment of effects with broad externalizing and impulsivity phenotypes in an independent sample
Creators: Fazil Aliev - Karabük University
Leah Wetherill - Indiana University
Laura Bierut - Washington University in St. Louis
Kathleen K Bucholz - Washington University in St. Louis
Howard Edenberg - Indiana University
Tatiana Foroud - Indiana University
Danielle M Dick - Virginia Commonwealth University
Collaborative Study on the Genetics of Alcoholism (COGA) Investigators
Contributors: Samuel Kuperman (Contributor) - University of Iowa, Psychiatry
Resource Type: Journal article
Publication Details: Journal of studies on alcohol and drugs, Vol.76(1), pp.38-46
DOI: 10.15288/jsad.2015.76.38
PMID: 25486392
PMCID: PMC4263779
NLM abbreviation: J Stud Alcohol Drugs
ISSN: 1937-1888
eISSN: 1938-4114
Grant note: K02 AA018755 / NIAAA NIH HHS U10AA008401 / NIAAA NIH HHS K02AA018755 / NIAAA NIH HHS U10 AA008401 / NIAAA NIH HHS
Language: English
Date published: 01/2015
Academic Unit: Psychiatry
Record Identifier: 9984293653002771

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