Journal article
Genetic Analysis of a Papillary Thyroid Carcinoma in a Patient with MEN1
Annals of surgical oncology, Vol.8(4), pp.342-346
05/2001
DOI: 10.1007/s10434-001-0342-8
PMID: 11352308
Abstract
Background: MEN1 is an inherited tumor syndrome characterized by the development of tumors of the parathyroid, the anterior pituitary and the pancreatic islets. Tumors of these endocrine glands in MEN1 patients demonstrate loss of heterozygosity (LOH) at the locus of the MEN1 tumor suppressor gene. Menin, the protein encoded by the MEN1 gene, is ubiquitously expressed in endocrine tissue, and less commonly these patients can present with tumors of other endocrine tissues, including thyroid and adrenal. We hypothesize that MEN1 gene mutation may be involved in the oncogenesis of other less common tumors.Methods: We report a MEN1 patient who was found to have metastatic papillary thyroid cancer at the time of neck exploration for hyperparathyroidism. Genetic analysis of tumor tissue was performed using one intragenic (D11S4946) and two flanking (D11S4945 and D11S4940) polymorphic markers.Results: Two of the markers were informative. Consistent with previous studies, there was LOH in the parathyroid adenoma identified with the intragenic marker D11S4946. However, the papillary cancer was found to be heterozygous at two informative markers.Conclusions: The lack of obvious LOH of the MEN1 locus in the papillary cancer suggests that, in contrast to parathyroid adenoma, deletion of the MEN1 tumor suppressor gene is not etiologically related to the oncogenesis of the papillary cancer in this patient.
Details
- Title: Subtitle
- Genetic Analysis of a Papillary Thyroid Carcinoma in a Patient with MEN1
- Creators
- Dev Desai - Department of Surgery (DD, LAMc, RJW) Stanford University School of Medicine Stanford CaliforniaLisa McPherson - Department of Surgery (DD, LAMc, RJW) Stanford University School of Medicine Stanford CaliforniaJohn Higgins - Department of Pathology (JPTH) Stanford University School of Medicine Stanford CaliforniaRonald Weigel - Stanford University School of Medicine Room P214, MSLS Stanford CA 94305-5494
- Resource Type
- Journal article
- Publication Details
- Annals of surgical oncology, Vol.8(4), pp.342-346
- Publisher
- Springer-Verlag; New York
- DOI
- 10.1007/s10434-001-0342-8
- PMID
- 11352308
- ISSN
- 1068-9265
- eISSN
- 1534-4681
- Language
- English
- Date published
- 05/2001
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984024565602771
Metrics
18 Record Views