Journal article
Genetic Approaches to Understanding Psychiatric Disease
Neurotherapeutics, Vol.14(3), pp.564-581
07/2017
DOI: 10.1007/s13311-017-0551-x
PMCID: PMC5509640
PMID: 28608171
Abstract
Human genetic studies have been the driving force in bringing to light the underlying biology of psychiatric conditions. As these studies fill in the gaps in our knowledge of the mechanisms at play, we will be better equipped to design therapies in rational and targeted ways, or repurpose existing therapies in previously unanticipated ways. This review is intended for those unfamiliar with psychiatric genetics as a field and provides a primer on different modes of genetic variation, the technologies currently used to probe them, and concepts that provide context for interpreting the gene-phenotype relationship. Like other subfields in human genetics, psychiatric genetics is moving from microarray technology to sequencing-based approaches as barriers of cost and expertise are removed, and the ramifications of this transition are discussed here. A summary is then given of recent genetic discoveries in a number of neuropsychiatric conditions, with particular emphasis on neurodevelopmental conditions. The general impact of genetics on drug development has been to underscore the extensive etiological heterogeneity in seemingly cohesive diagnostic categories. Consequently, the path forward is not in therapies hoping to reach large swaths of patients sharing a clinically defined diagnosis, but rather in targeting patients belonging to specific "biotypes" defined through a combination of objective, quantifiable data, including genotype.
Details
- Title: Subtitle
- Genetic Approaches to Understanding Psychiatric Disease
- Creators
- Jacob J Michaelson - University of Iowa Informatics Initiative, University of Iowa, Iowa City, IA, USA. jacob-michaelson@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Neurotherapeutics, Vol.14(3), pp.564-581
- Publisher
- United States
- DOI
- 10.1007/s13311-017-0551-x
- PMID
- 28608171
- PMCID
- PMC5509640
- ISSN
- 1933-7213
- eISSN
- 1878-7479
- Grant note
- R01 DC014489 / NIDCD NIH HHS R01 MH105527 / NIMH NIH HHS
- Language
- English
- Date published
- 07/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Communication Sciences and Disorders; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070002202771
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