Genetic Basis of Alopecia Areata: A Roadmap for Translational Research

Ali Jabbari; Lynn Petukhova; Rita M Cabral; Raphael Clynes; Angela M Christiano

doi:10.1016/j.det.2012.08.014

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Genetic Basis of Alopecia Areata: A Roadmap for Translational Research

Journal article

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Peer reviewed

Genetic Basis of Alopecia Areata: A Roadmap for Translational Research

Ali Jabbari, Lynn Petukhova, Rita M Cabral, Raphael Clynes and Angela M Christiano

Dermatologic clinics, Vol.31(1), pp.109-117

01/2013

DOI: 10.1016/j.det.2012.08.014

PMCID: PMC4362526

PMID: 23159180

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Abstract

Alopecia Areata (AA) is a recurrent autoimmune type of hair loss that affects about 5.3 million people in the United States alone. Despite being the most prevalent autoimmune disease, affecting more individuals than most other autoimmune diseases combined, the molecular and cellular mechanisms underlying this complex disease are still poorly understood, and rational treatments are lacking. It is currently accepted that AA is an autoimmune disease that occurs in genetically susceptible individuals and that environmental factors play a role in the development and progression of the disease. However, further efforts are necessary to clearly pinpoint the causes and molecular pathways leading to this disease and, most importantly, to find evidence-based treatments to treat AA. Here, we will focus on the central role of genetics for gaining insight into disease pathogenesis and setting the stage for the rational development of novel effective therapeutic approaches. This is an exciting new era marking the beginning of translational research in AA based on genetic findings.

Details

Title: Subtitle: Genetic Basis of Alopecia Areata: A Roadmap for Translational Research
Creators: Ali Jabbari - Department of Dermatology, Columbia University, Russ Berrie Medical Science Pavilion, 1150 Saint Nicholas Avenue, New York, NY 10032, United States
Lynn Petukhova - Department of Dermatology, Columbia University, Russ Berrie Medical Science Pavilion, 1150 Saint Nicholas Avenue, New York, NY 10032, United States
Rita M Cabral - Department of Dermatology, Columbia University, Russ Berrie Medical Science Pavilion, 1150 Saint Nicholas Avenue, New York, NY 10032, United States
Raphael Clynes - Department of Dermatology, Columbia University, Russ Berrie Medical Science Pavilion, 1150 Saint Nicholas Avenue, New York, NY 10032, United States
Angela M Christiano - Department of Dermatology, Columbia University, Russ Berrie Medical Science Pavilion, 1150 Saint Nicholas Avenue, New York, NY 10032, United States
Resource Type: Journal article
Publication Details: Dermatologic clinics, Vol.31(1), pp.109-117
DOI: 10.1016/j.det.2012.08.014
PMID: 23159180
PMCID: PMC4362526
NLM abbreviation: Dermatol Clin
ISSN: 0733-8635
eISSN: 1558-0520
Language: English
Date published: 01/2013
Academic Unit: Dermatology
Record Identifier: 9984025463402771

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