Genetic Causes of Hearing Loss in a Large Cohort of Cochlear Implant Recipients

Kristen L Seligman; A Eliot Shearer; Kathy Frees; Carla Nishimura; Diana Kolbe; Camille Dunn; Marlan R Hansen; Bruce J Gantz; Richard J H Smith

doi:10.1177/01945998211021308

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Genetic Causes of Hearing Loss in a Large Cohort of Cochlear Implant Recipients

Journal article

Peer reviewed

Genetic Causes of Hearing Loss in a Large Cohort of Cochlear Implant Recipients

Kristen L Seligman, A Eliot Shearer, Kathy Frees, Carla Nishimura, Diana Kolbe, Camille Dunn, Marlan R Hansen, Bruce J Gantz and Richard J H Smith

Otolaryngology-head and neck surgery, Vol.166(4), pp.734-737

04/2022

DOI: 10.1177/01945998211021308

PMCID: PMC9128025

PMID: 34154485

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https://www.ncbi.nlm.nih.gov/pmc/articles/9128025View

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Abstract

Understanding genetic causes of hearing loss can determine the pattern and course of a patient's hearing loss and may also predict outcomes after cochlear implantation. Our goal in this study was to evaluate genetic causes of hearing loss in a large cohort of adults and children with cochlear implants. We performed comprehensive genetic testing on all patients undergoing cochlear implantation. Of the 459 patients included in the study, 128 (28%) had positive genetic testing. In total, 44 genes were identified as causative. The top 5 genes implicated were (20, 16%), (13, 10%), (10, 8%), (9, 7%), and (7, 5%). Pediatric patients had a higher diagnostic rate. This study lays the groundwork for future studies evaluating the relationship between genetic variation and cochlear implant performance.

Adult

Child

Cochlear Implantation

Cochlear Implants

Cohort Studies

Deafness - genetics

Hearing Loss - genetics

Hearing Loss - surgery

Humans

Membrane Proteins - genetics

Neoplasm Proteins

Serine Endopeptidases - genetics

Details

Title: Subtitle: Genetic Causes of Hearing Loss in a Large Cohort of Cochlear Implant Recipients
Creators: Kristen L Seligman - Roy J. and Lucille A. Carver College of Medicine
A Eliot Shearer - Boston Children's Hospital
Kathy Frees - University of Iowa
Carla Nishimura - University of Iowa
Diana Kolbe - University of Iowa
Camille Dunn - University of Iowa
Marlan R Hansen - University of Iowa
Bruce J Gantz - University of Iowa
Richard J H Smith - University of Iowa
Resource Type: Journal article
Publication Details: Otolaryngology-head and neck surgery, Vol.166(4), pp.734-737
DOI: 10.1177/01945998211021308
PMID: 34154485
PMCID: PMC9128025
NLM abbreviation: Otolaryngol Head Neck Surg
ISSN: 0194-5998
eISSN: 1097-6817
Grant note: P50 DC000242 / NIDCD NIH HHS R01 DC017955 / NIDCD NIH HHS
Language: English
Date published: 04/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Communication Sciences and Disorders; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology; Internal Medicine; Iowa Institute of Human Genetics
Record Identifier: 9984256841902771

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