Journal article
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
Cell (Cambridge), Vol.88(5), pp.615-626
1997
DOI: 10.1016/S0092-8674(00)81904-2
PMID: 9054501
Abstract
To explore the role of protein kinase A (PKA) in the late phase of long-term potentiation (L-LTP) and memory, we generated transgenic mice that express R(AB), an inhibitory form of the regulatory subunit of PKA, only in the hippocampus and other forebrain regions by using the promoter from the gene encoding Ca
2+/calmodulin protein kinase IIα. In these
R(AB) transgenic mice, hippocampal PKA activity was reduced, and L-LTP was significantly decreased in area CA1, without affecting basal synaptic transmission or the early phase of LTP. Moreover, the L-LTP deficit was paralleled by behavioral deficits in spatial memory and in long-term but not short-term memory for contextual fear conditioning. These deficits in long-term memory were similar to those produced by protein synthesis inhibition. Thus, PKA plays a critical role in the consolidation of long-term memory.
Details
- Title: Subtitle
- Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
- Creators
- Ted Abel - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USAPeter V Nguyen - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USAMark Barad - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USAThomas A.S Deuel - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USAEric R Kandel - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USARoussoudan Bourtchouladze - Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.88(5), pp.615-626
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0092-8674(00)81904-2
- PMID
- 9054501
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 1997
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065827802771
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