Journal article
Genetic Disruption of Protein Kinase A Anchoring Reveals a Role for Compartmentalized Kinase Signaling in Theta-Burst Long-Term Potentiation and Spatial Memory
The Journal of neuroscience, Vol.27(38), pp.10278-10288
09/19/2007
DOI: 10.1523/JNEUROSCI.1602-07.2007
PMCID: PMC2927986
PMID: 17881534
Abstract
Studies of hippocampal long-term potentiation (LTP), a cellular model of memory storage, implicate cAMP-dependent protein kinase (PKA) in presynaptic and postsynaptic mechanisms of LTP. The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized pools of PKA, but the roles of presynaptically and postsynaptically anchored forms of PKA in late-phase LTP are unclear. In this study, we have created genetically modified mice that conditionally express Ht31, an inhibitor of PKA anchoring, to probe the roles of anchored PKA in hippocampal LTP and spatial memory. Our findings show that at hippocampal Schaffer collateral CA3–CA1 synapses, theta-burst LTP requires presynaptically anchored PKA. In addition, a pool of anchored PKA in hippocampal area CA3 is required for spatial memory. These findings reveal a novel and significant role for anchored PKA signaling in cellular mechanisms underlying memory storage.
Details
- Title: Subtitle
- Genetic Disruption of Protein Kinase A Anchoring Reveals a Role for Compartmentalized Kinase Signaling in Theta-Burst Long-Term Potentiation and Spatial Memory
- Creators
- Ting Nie - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, andConor B McDonough - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, andTed Huang - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, andPeter V Nguyen - Departments of Physiology and Psychiatry, Centre for Neuroscience, University of Alberta School of Medicine, Edmonton, Alberta, Canada T6G 2H7Ted Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.27(38), pp.10278-10288
- Publisher
- Society for Neuroscience
- DOI
- 10.1523/JNEUROSCI.1602-07.2007
- PMID
- 17881534
- PMCID
- PMC2927986
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Language
- English
- Date published
- 09/19/2007
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065833202771
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