Journal article
Genetic Diversity of the Human Serotonin Receptor 1B (HTR1B) Gene
Genomics (San Diego, Calif.), Vol.72(1), pp.1-14
02/15/2001
DOI: 10.1006/geno.2000.6411
PMID: 11247661
Abstract
We systematically and comprehensively investigated polymorphisms of the HTR1B gene as well as their linkage disequilibrium and ancestral relationships. We have detected the following polymorphisms in our sample via denaturing gradient gel electrophoresis, database comparisons, and/or previously published assays: G-511T, T-261G, –182INS/DEL-181, A-161T, C129T, T371G, T655C, C705T, G861C, A1099G, G1120A, and A1180G. The results of the intermarker analyses showed strong linkage disequilibrium between the C129T and the G861C polymorphisms and revealed four common haplotypes: ancestral (via chimpanzee comparisons), 129T/861C, -161T, and -182DEL-181. The results of association tests with schizophrenia were negative, although A-161T had a nominal P = 0.04 via ASPEX/sib_tdt. The expressed missense substitutions, Phe124Cys, Phe219Leu, Ile367Val, and Glu374Lys, could potentially affect ligand binding or interaction with G proteins and thus modify drug response in carriers of these variants. On average, the human cSNPs and differences among other primates clustered in the more thermodynamically unstable regions of the mRNA, which suggests that the evolutionary survival of nucleotide sequence variation may be influenced by the mRNA structure of this gene.
Details
- Title: Subtitle
- Genetic Diversity of the Human Serotonin Receptor 1B (HTR1B) Gene
- Creators
- Alan R Sanders - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637Qiuhe Cao - Unit on Molecular Clinical Investigation, Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland, 20892Jennifer Taylor - National Institute of Mental HealthTamara E Levin - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637Judith A Badner - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637Anibal Cravchik - Unit on Molecular Clinical Investigation, Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland, 20892Josep M Comeron - University of Iowa, BiologySaitou Naruya - Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima, JapanAmado Del Rosario - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637Debra A Salvi - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637Katherine A Walczyk - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637Bryan J Mowry - Department of Psychiatry, University of Queensland, Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Brisbane, Queensland, AustraliaDouglas F Levinson - Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104Raymond R Crowe - University of Iowa, PsychiatryJeremy M Silverman - Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, 10029Pablo V Gejman - Schizophrenia Genetics Research Program, Department of Psychiatry, The University of Chicago, Chicago, Illinois, 60637
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.72(1), pp.1-14
- DOI
- 10.1006/geno.2000.6411
- PMID
- 11247661
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 02/15/2001
- Academic Unit
- Psychiatry; Biology
- Record Identifier
- 9983991997902771
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