Journal article
Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight
JAMA : the journal of the American Medical Association, Vol.315(11), pp.1129-1140
03/15/2016
DOI: 10.1001/jama.2016.1975
PMCID: PMC4811305
PMID: 26978208
Abstract
Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain.
Details
- Title: Subtitle
- Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight
- Creators
- Jessica Tyrrell - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom2European Centre for Environment and Human Health, University of Exeter, the Knowledge Spa, Truro, United KingdomRebecca C Richmond - School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom4The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands5Medical Research Council InteTom M Palmer - Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom7Department of Mathematics and Statistics, Lancaster University, Lancaster, United KingdomBjarke Feenstra - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkJanani Rangarajan - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisSarah Metrustry - Department of Twin Research, King's College London, St Thomas' Hospital, London, United KingdomAlana Cavadino - Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts, and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom12Population, Policy and Practice, UCL Institute of Child HeLavinia Paternoster - Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United KingdomLoren L Armstrong - Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisN Maneka G De Silva - Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United KingdomAndrew R Wood - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United KingdomMomoko Horikoshi - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom15Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United KingdomFrank Geller - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, DenmarkRonny Myhre - Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, NorwayJonathan P Bradfield - Center for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, PennsylvaniaEskil Kreiner-Møller - Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, and Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, DenmarkVille Huikari - Institute of Health Sciences, University of Oulu, Oulu, FinlandJodie N Painter - QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, AustraliaJouke-Jan Hottenga - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands22Department of Biological Psychology, VU University Amsterdam, Amsterdam, the NetherlandsCatherine Allard - Department of Mathematics, Universite de Sherbrooke, Quebec City, Quebec, Canada24Centre de recherché du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec City, Quebec, CanadaDiane J Berry - Population, Policy and Practice, UCL Institute of Child Health, University College London, United KingdomLuigi Bouchard - Centre de recherché du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec City, Quebec, Canada25ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, Quebec City, Quebec, Canada26Department of Biochemistry, Université de SherbrookeShikta Das - Department of Primary Care and Public Health, Imperial College London, United KingdomDavid M Evans - School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom28University of Queensland DiamantinHakon Hakonarson - Center for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania29Division of Human Genetics, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania30Department of Pediatrics, Perelman School of Medicine, UniveM Geoffrey Hayes - Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisJani Heikkinen - FIMM Institute for Molecular Medicine Finland, Helsinki University, Helsinki, FinlandAlbert Hofman - Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands54Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MassachusettsBridget Knight - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United KingdomPenelope A Lind - QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, AustraliaMark I McCarthy - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom15Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom33Oxford National Institute for Health Research (NIHR) Biomedical ResearcGeorge McMahon - School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United KingdomSarah E Medland - QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, AustraliaMads Melbye - Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark34Department of Medicine, Stanford University School of Medicine, Stanford, CaliforniaAndrew P Morris - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom35Department of Biostatistics, University of Liverpool, Liverpool, United KingdomMichael Nodzenski - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisChristoph Reichetzeder - Institute of Nutritional Science, University of Potsdam, Germany37Center for Cardiovascular Research/Charité, Berlin, GermanySusan M Ring - School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United KingdomSylvain Sebert - Institute of Health Sciences, University of Oulu, Oulu, Finland38Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial CollVerena Sengpiel - Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, SwedenThorkild I A Sørensen - Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom40Institute of Preventive Medicine, Bispebjerg and Frederiksberg University Hospital, Capital Region, Copenhagen, Denmark41Novo Nordisk Foundation Center foGonneke Willemsen - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands22Department of Biological Psychology, VU University Amsterdam, Amsterdam, the NetherlandsEco J C de Geus - EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands22Department of Biological Psychology, VU University Amsterdam, Amsterdam, the NetherlandsNicholas G Martin - QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, AustraliaTim D Spector - Department of Twin Research, King's College London, St Thomas' Hospital, London, United KingdomChristine Power - Population, Policy and Practice, UCL Institute of Child Health, University College London, United KingdomMarjo-Riitta Järvelin - Institute of Health Sciences, University of Oulu, Oulu, Finland38Department of Epidemiology and Biostatistics, School of Public Health, Medical Research Council-Health Protection Agency Centre for Environment and Health, Faculty of Medicine, Imperial CollHans Bisgaard - Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, and Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, DenmarkStruan F A Grant - Center for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania29Division of Human Genetics, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania30Department of Pediatrics, Perelman School of Medicine, UniveEllen A Nohr - Research Unit of Obstetrics & Gynecology, Institute of Clinical Research, University of Southern Denmark, OdenseVincent W Jaddoe - The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands32Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands46Department of Pediatrics, Erasmus MC, University MedicBo Jacobsson - Division of Epidemiology, Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway39Department of Obstetrics and Gynecology, Sahlgrenska Academy, Sahgrenska University Hospital, Gothenburg, SwedenJeffrey C Murray - Department of Pediatrics, University of Iowa, Iowa CityBerthold Hocher - Institute of Nutritional Science, University of Potsdam, Germany48The First Affiliated Hospital of Jinan University, Guangzhou, ChinaAndrew T Hattersley - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United KingdomDenise M Scholtens - Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisGeorge Davey Smith - School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United KingdomMarie-France Hivert - Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, Massachusetts50Diabetes Center, Massachusetts General Hospital, Boston51Department of Medicine, Universite de Sherbrooke, Quebec City, Quebec, CanadaJanine F Felix - The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands32Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands46Department of Pediatrics, Erasmus MC, University MedicElina Hyppönen - Population, Policy and Practice, UCL Institute of Child Health, University College London, United Kingdom52Centre for Population Health Research, School of Health Sciences, and Sansom Institute, University of South Australia, Adelaide53South Australian HeWilliam L Lowe Jr - Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IllinoisTimothy M Frayling - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United KingdomDebbie A Lawlor - School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United KingdomRachel M Freathy - Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom
- Resource Type
- Journal article
- Publication Details
- JAMA : the journal of the American Medical Association, Vol.315(11), pp.1129-1140
- DOI
- 10.1001/jama.2016.1975
- PMID
- 26978208
- PMCID
- PMC4811305
- NLM abbreviation
- JAMA
- ISSN
- 0098-7484
- eISSN
- 1538-3598
- Publisher
- United States
- Grant note
- R01 HD056465 / NICHD NIH HHS WT083431MF / Wellcome Trust MC_UU_12013/1 / Medical Research Council MR/J012165/1 / Medical Research Council Canadian Institutes of Health Research G0500070 / Medical Research Council 104150/Z/14/Z / Wellcome Trust 323195 / European Research Council MC_PC_15018 / Medical Research Council 098395 / Wellcome Trust 102215 / Wellcome Trust G0601261 / Medical Research Council WT088806 / Wellcome Trust MC_UU_12013/5 / Medical Research Council 104150 / Wellcome Trust WT098017 / Wellcome Trust MR/N01104X/1 / Medical Research Council G1001799 / Medical Research Council R01 DK10324 / NIDDK NIH HHS WT094529MA / Wellcome Trust MC_UU_1201/4 / Medical Research Council MC_UU_1201/1/5 / Medical Research Council P30 ES013508 / NIEHS NIH HHS MC_UU_1201/1 / Medical Research Council R01 DK103246 / NIDDK NIH HHS MC_UU_12013/3 / Medical Research Council MC_UU_12013/4 / Medical Research Council G0701603 / Medical Research Council
- Language
- English
- Date published
- 03/15/2016
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025365202771
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