Genetic, Immunologic, and Environmental Basis of Sarcoidosis

David R Moller; Ben A Rybicki; Nabeel Y Hamzeh; Courtney G Montgomery; Edward S Chen; Wonder Drake; Andrew P Fontenot

doi:10.1513/AnnalsATS.201707-565OT

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Genetic, Immunologic, and Environmental Basis of Sarcoidosis

Journal article

Open access

Peer reviewed

Genetic, Immunologic, and Environmental Basis of Sarcoidosis

David R Moller, Ben A Rybicki, Nabeel Y Hamzeh, Courtney G Montgomery, Edward S Chen, Wonder Drake and Andrew P Fontenot

Annals of the American Thoracic Society, Vol.14(Supplement_6), pp.S429-S436

12/2017

DOI: 10.1513/AnnalsATS.201707-565OT

PMCID: PMC5822412

PMID: 29073364

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Abstract

Sarcoidosis is a multisystem disease with tremendous heterogeneity in disease manifestations, severity, and clinical course that varies among different ethnic and racial groups. To better understand this disease and to improve the outcomes of patients, a National Heart, Lung, and Blood Institute workshop was convened to assess the current state of knowledge, gaps, and research needs across the clinical, genetic, environmental, and immunologic arenas. We also explored to what extent the interplay of the genetic, environmental, and immunologic factors could explain the different phenotypes and outcomes of patients with sarcoidosis, including the chronic phenotypes that have the greatest healthcare burden. The potential use of current genetic, epigenetic, and immunologic tools along with study approaches that integrate environmental exposures and precise clinical phenotyping were also explored. Finally, we made expert panel-based consensus recommendations for research approaches and priorities to improve our understanding of the effect of these factors on the health outcomes in sarcoidosis.

Environmental Exposure - adverse effects

Phenotype

National Heart, Lung, and Blood Institute (U.S.)

United States

Humans

Risk Factors

Sarcoidosis - immunology

Sarcoidosis - genetics

Biomedical Research - trends

Consensus

Details

Title: Subtitle: Genetic, Immunologic, and Environmental Basis of Sarcoidosis
Creators: David R Moller - 1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland
Ben A Rybicki - 2 Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan
Nabeel Y Hamzeh - 3 National Jewish Health, Denver, Colorado
Courtney G Montgomery - 4 Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
Edward S Chen - 1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore Maryland
Wonder Drake - 5 Vanderbilt University School of Medicine, Nashville, Tennessee; and
Andrew P Fontenot - 6 Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado
Resource Type: Journal article
Publication Details: Annals of the American Thoracic Society, Vol.14(Supplement_6), pp.S429-S436
DOI: 10.1513/AnnalsATS.201707-565OT
PMID: 29073364
PMCID: PMC5822412
NLM abbreviation: Ann Am Thorac Soc
ISSN: 2325-6621
eISSN: 2325-6621
Publisher: American Thoracic Society
Grant note: U01 HL112695 / NHLBI NIH HHS R01 HL114587 / NHLBI NIH HHS R01 HL136137 / NHLBI NIH HHS U01 HL112708 / NHLBI NIH HHS U01 HL112694 / NHLBI NIH HHS R01 HL113326 / NHLBI NIH HHS K24 HL127301 / NHLBI NIH HHS
Language: English
Date published: 12/2017
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094336502771

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