Journal article
Genetic Influences on Alcohol Use across Stages of Development: GABRA2 and Longitudinal Trajectories of Drunkenness from Adolescence to Young Adulthood
Addiction biology, Vol.19(6), pp.1055-1064
11/2014
DOI: 10.1111/adb.12066
PMCID: PMC3783626
PMID: 23692184
Abstract
Longitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of
GABRA2
, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. We use data from 1070 individuals who participated in the prospective sample of the Collaborative Study on the Genetics of Alcoholism (COGA), in order to better understand the unfolding of genetic risk across development. Piecewise linear growth models were fit to model the influence of genotype on rate of increase in drunkenness from early adolescence to young adulthood (14–18 years), the change in drunkenness during the transition to adulthood (18–19 years), and the rate of change in drunkenness across young adulthood (≥ 19 years). Variation in
GABRA2
was associated with an increase in drunkenness that occurred at the transition between adolescence and adulthood. The genotypic effect was more pronounced in females. These analyses illustrate the importance of longitudinal data to characterize how genetic effects unfold across development. The findings suggest that transitions across important developmental periods may alter the relative importance of genetic effects on patterns of alcohol use. The findings also suggest the importance of considering gender when evaluating genetic effects on drinking patterns in males and females.
Details
- Title: Subtitle
- Genetic Influences on Alcohol Use across Stages of Development: GABRA2 and Longitudinal Trajectories of Drunkenness from Adolescence to Young Adulthood
- Creators
- Danielle M Dick - University of Iowa College of Medicine, Iowa City, IASeung Bin Cho - University of Iowa College of Medicine, Iowa City, IAShawn J Latendresse - University of Iowa College of Medicine, Iowa City, IAFazil Aliev - University of Iowa College of Medicine, Iowa City, IAJohn I Nurnberger - University of Iowa College of Medicine, Iowa City, IAHoward J Edenberg - University of Iowa College of Medicine, Iowa City, IAMarc Schuckit - University of Iowa College of Medicine, Iowa City, IAVictor M Hesselbrock - University of Iowa College of Medicine, Iowa City, IABernice Porjesz - University of Iowa College of Medicine, Iowa City, IAKathleen Bucholz - University of Iowa College of Medicine, Iowa City, IAJen-Chyong Wang - University of Iowa College of Medicine, Iowa City, IAAlison Goate - University of Iowa College of Medicine, Iowa City, IAJohn R Kramer - University of Iowa College of Medicine, Iowa City, IASamuel Kuperman - University of Iowa College of Medicine, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Addiction biology, Vol.19(6), pp.1055-1064
- DOI
- 10.1111/adb.12066
- PMID
- 23692184
- PMCID
- PMC3783626
- ISSN
- 1355-6215
- eISSN
- 1369-1600
- Language
- English
- Date published
- 11/2014
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003442002771
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