Journal article
Genetic Moderation of Contextual Effects on Negative Arousal and Parenting in African-American Parents
Journal of family psychology, Vol.26(1), pp.46-55
02/2012
DOI: 10.1037/a0026236
PMCID: PMC3274648
PMID: 22081909
Abstract
A three-stage
context amplification model was tested with a sample of 345 African-American
parent-child dyads. The model combined the conceptual structure of stress
generation with recent findings regarding genetic susceptibility. Because the 7R
+ allele of the dopamine transporter (DRD4) has the potential
to enhance contextual priming and arousal, this allele was examined as a
potential moderator of each stage of the amplification process. Particular
attention was given to the hypothesized influence of parental negative arousal
on valence of parent-child interactions. The literature on genetic
susceptibility led to the hypothesis that DRD4 would moderate
each stage of the model in a "for better or for worse" manner. The
model was partially supported. DRD4 moderated effects at all
three stages of the model and, as hypothesized, DRD4 moderated
contextual effects on negative arousal in a "for better or for
worse" manner. Effects on parent-child interaction, however, were
moderated in a "for worse" manner only. These results indicate that
parenting interactions may amplify the effects of positive and negative contexts
in a stress-generating manner, and that a susceptibility framework captures the
way in which DRD4 moderates the impact of context on negative
arousal.
Details
- Title: Subtitle
- Genetic Moderation of Contextual Effects on Negative Arousal and Parenting in African-American Parents
- Creators
- Steven R. H Beach - Center for Contextual Genetics and Prevention Science, University of GeorgiaMan Kit Lei - Center for Contextual Genetics and Prevention Science, University of GeorgiaGene H Brody - Center for Contextual Genetics and Prevention Science, University of GeorgiaRonald L Simons - Center for Contextual Genetics and Prevention Science, University of GeorgiaCarolyn Cutrona - Department of Psychology, Iowa State UniversityRobert A Philibert - Department of Psychiatry, Neuroscience and Genetics Programs, University of Iowa
- Contributors
- Nadine J Kaslow (Editor)
- Resource Type
- Journal article
- Publication Details
- Journal of family psychology, Vol.26(1), pp.46-55
- DOI
- 10.1037/a0026236
- PMID
- 22081909
- PMCID
- PMC3274648
- NLM abbreviation
- J Fam Psychol
- ISSN
- 0893-3200
- eISSN
- 1939-1293
- Publisher
- American Psychological Association
- Grant note
- DOI: 10.13039/100000025, name: National Institute of Mental Health, award: MH080898, 2 R01 MH062666-06; DOI: 10.13039/100000026, name: National Institute on Drug Abuse, award: 1P30DA027827-01
- Language
- English
- Date published
- 02/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003432002771
Metrics
34 Record Views