Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia

N F Banks; P M Tomko; R J Colquhoun; T W D Muddle; S R Emerson; N D M Jenkins

doi:10.1038/s41598-019-46931-0

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Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia

Journal article

Open access

Peer reviewed

Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia

N F Banks, P M Tomko, R J Colquhoun, T W D Muddle, S R Emerson and N D M Jenkins

Scientific reports, Vol.9(1), pp.10532-9

07/19/2019

DOI: 10.1038/s41598-019-46931-0

PMCID: PMC6642114

PMID: 31324842

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Abstract

The liver enzyme cytochrome P450 1A2 (CYP1A2) is responsible for 90% of caffeine metabolism, while caffeine exerts many of its effects via antagonist binding to adenosine A2a receptors (ADORA2A). This study aimed to examine whether functional single nucleotide polymorphisms (SNPs) in 1976T > C (ADORA2A; rs5751876) and -163C > A (CYP1A2; rs762551) influence the effect of caffeine on the postprandial glucose (GLU) response to a carbohydrate meal. We report that individuals with the 1976T > C CC, but not CT/TT genotypes display elevated GLU levels after consuming caffeine and carbohydrate (CHO + CAFF) versus carbohydrate only (CHO). The GLU area under the curve (AUC) was also greater during the CHO + CAFF condition compared to the CHO condition in CC, but not the CT/TT genotypes. The -163C > A AC/CC, but not AA, genotypes displayed greater GLU concentrations 60-min post meal during CHO + CAFF versus CHO. Our data suggest that caffeine-induced impairments in postprandial glycaemia are related to 1976T > C and -163C > A SNPs.

Adolescent

Adult

Area Under Curve

Blood Glucose - analysis

Body Composition

Caffeine - pharmacokinetics

Caffeine - pharmacology

Cytochrome P-450 CYP1A2 - genetics

Dietary Carbohydrates - metabolism

Dietary Carbohydrates - pharmacology

Exercise

Genotype

Glucose - pharmacology

Humans

Hyperglycemia - genetics

Male

Polymorphism, Single Nucleotide

Receptor, Adenosine A2A - drug effects

Receptor, Adenosine A2A - genetics

Single-Blind Method

Sucrose - pharmacology

Young Adult

Details

Title: Subtitle: Genetic Polymorphisms in ADORA2A and CYP1A2 Influence Caffeine's Effect on Postprandial Glycaemia
Creators: N F Banks - Oklahoma State University
P M Tomko - Oklahoma State University
R J Colquhoun - Oklahoma State University
T W D Muddle - Oklahoma State University
S R Emerson - Oklahoma State University
N D M Jenkins - Oklahoma State University
Resource Type: Journal article
Publication Details: Scientific reports, Vol.9(1), pp.10532-9
DOI: 10.1038/s41598-019-46931-0
PMID: 31324842
PMCID: PMC6642114
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Grant note: P20 GM109097 / NIGMS NIH HHS
Language: English
Date published: 07/19/2019
Academic Unit: Center for Social Science Innovation; Injury Prevention Research Center; Health, Sport, and Human Physiology
Record Identifier: 9984259655802771

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