Journal article
Genetic Predictors of Knee Pain in Persons With Mild to Moderate Osteoarthritis
Research in gerontological nursing, Vol.13(4), pp.1-202
04/13/2020
DOI: 10.3928/19404921-20200312-01
PMID: 32286672
Abstract
The purpose of this study was to examine genetic variability and knee pain in persons with osteoarthritis (OA). Seventy-five participants with medial compartment knee OA were recruited from a large Midwestern tertiary care center. Participants exhibited a mean age of 56.3 years; females comprised 61% of the sample. Measures of pain included subjective pain intensity at rest and with movement, cutaneous mechanical sensation and pain testing, heat pain threshold, and pressure pain threshold. Seventy-four participants were genotyped for 25 genetic variants across 15 candidate genes for central or peripheral pain pathways. Analysis suggests a role for four genes (EDNRA, COMT, BDRKB1, and IL1B) in several components of pain in persons with knee OA. The results from this study will help guide the development and evaluation of tailored strategies to decrease pain, improve function, and prevent the development of new chronic pain syndromes in older adults experiencing OA. [Research in Gerontological Nursing, xx(x), xx-xx.].
Details
- Title: Subtitle
- Genetic Predictors of Knee Pain in Persons With Mild to Moderate Osteoarthritis
- Creators
- Debra L SchutteN MukhopadhyayTeri HolwerdaKathleen SlukaBarbara RakelManika Govil
- Resource Type
- Journal article
- Publication Details
- Research in gerontological nursing, Vol.13(4), pp.1-202
- Publisher
- United States
- DOI
- 10.3928/19404921-20200312-01
- PMID
- 32286672
- ISSN
- 1940-4921
- eISSN
- 1938-2464
- Language
- English
- Date published
- 04/13/2020
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984070715902771
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