Journal article
Genetic Risk Scores for Maternal Lipid Levels and Their Association with Preterm Birth
Lipids, Vol.54(10), pp.641-650
10/2019
DOI: 10.1002/lipd.12186
PMID: 31468542
Abstract
Maternal lipid profiles are associated with risk for preterm birth (PTB), although the lipid component and effect size are inconsistent between studies. It is also unclear whether these associations are the result of excessive changes in lipid metabolism during pregnancy or genetic variability in genes controlling basal lipid metabolism. This study investigates the association between genetic risk scores (GRS) for four lipid components (high-density lipoprotein [HDL-C], low-density lipoprotein [LDL-C], triacylglycerols [TAG], and total cholesterol [TC]) with risk for PTB. Subjects included 954 pregnant women from California for whom second trimester serum samples were available, of which 479 gave birth preterm and 475 gave birth at term. We genotyped 96 single-nucleotide polymorphisms, which were selected from genome-wide association studies of lipid levels in adult populations. Lipid-specific GRS were constructed for HDL-C, LDL-C, TAG, and TC. The associations between GRS and PTB were analyzed using logistic regression. A higher HDL-C GRS was associated with increased risk for PTB overall and spontaneous PTB. Higher TAG and TC GRS were associated with decreased risk for PTB overall and spontaneous PTB. This study identifies counter-intuitive associations between lipid GRS and spontaneous PTB. Further replication studies are needed to confirm these findings, but they suggest that our current scientific understanding of the relationship between lipid metabolism, PTB, and genetics is incomplete.
Details
- Title: Subtitle
- Genetic Risk Scores for Maternal Lipid Levels and Their Association with Preterm Birth
- Creators
- Caitlin J Smith - University of IowaElizabeth A Jasper - University of IowaRebecca J Baer - University of California, San DiegoPatrick J Breheny - University of IowaRandi A Paynter - University of California, San FranciscoWei Bao - University of IowaJennifer G Robinson - University of IowaJohn M Dagle - University of IowaLaura L Jelliffe-Pawlowski - University of California, San FranciscoKelli K Ryckman - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Lipids, Vol.54(10), pp.641-650
- DOI
- 10.1002/lipd.12186
- PMID
- 31468542
- ISSN
- 0024-4201
- eISSN
- 1558-9307
- Grant note
- DOI: 10.13039/100000912, name: March of Dimes Foundation, award: 21‐FY13‐19
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Neonatology; Internal Medicine
- Record Identifier
- 9984193556102771
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