Journal article
Genetic Studies on Staphylococcal Strains from Patients with Toxic Shock Syndrome
Annals of internal medicine, Vol.96(6_Part_2), pp.974-977
06/01/1982
DOI: 10.7326/0003-4819-96-6-974
PMID: 6212007
Abstract
Thirteen isolates ofStaphylococcus aureusthat produce the toxic shock syndrome exotoxin were screened to identify and characterize this specific determinant and understand its role in pathogenicity. These stains belong to phage group 1, are sensitive to phage 29, and are similar with respect to their resistance to cadmium, arsenate, and penicillin. These three resistances, commonly found on plasmids in many strains ofS. aureus, were not plasmid-associated in 13 toxic shock strains. The cadmium and arsenate resistances were cotransferred both in transduction and in protoplast fusion; penicillin resistance was unlinked. The toxic syndrome exotoxin gene was not linked to any of these three traits. We suggest that the trait is borne by a special genetic element that acts as a heterologous chromosomal insertion and is independent of the cadmium-arsenate linkage group or the penicillinase determinant. The genetic properties of extracellular proteins inS. aureusare reviewed as possible models for the acquisition or expression of this toxic shock antigen
Details
- Title: Subtitle
- Genetic Studies on Staphylococcal Strains from Patients with Toxic Shock Syndrome
- Creators
- Barry N KreiswirthRichard P NovickPatrick M Schlievert - University of Iowa, Microbiology and ImmunologyMerlin Bergdoll
- Resource Type
- Journal article
- Publication Details
- Annals of internal medicine, Vol.96(6_Part_2), pp.974-977
- DOI
- 10.7326/0003-4819-96-6-974
- PMID
- 6212007
- ISSN
- 0003-4819
- eISSN
- 1539-3704
- Language
- English
- Date published
- 06/01/1982
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001224302771
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