Journal article
Genetic Variants and the Cortisol Response in Children: An Exploratory Study
Biological research for nursing, Vol.21(2), pp.157-165
03/2019
DOI: 10.1177/1099800419826315
PMCID: PMC6700893
PMID: 30700110
Abstract
Objective:
We examined genomic variation potentially associated with the cortisol stress response in children having a painful medical procedure.
Design:
Children 4–10 years old having a peripheral intravenous line inserted provided saliva samples for evaluation of the cortisol response as a biological measure of distress: two on the day of the procedure and two at home on a nonstressful day for comparison values. Children and biological parents also provided samples for genotyping of variants with known or suspected association with the cortisol stress response. Analysis included child-only association and family-based transmission disequilibrium tests (TDTs).
Results:
Genotype and phenotype data on the cortisol stress response were available from 326 children for child-only association analyses and 376 complete family trios for TDTs. Children were 50% female, an average of 7.5 years old, and mostly (83%) White/non-Hispanic. We identified four single-nucleotide polymorphisms (SNPs) potentially associated with the cortisol stress response: rs1176744 (HTR3B), rs10062367 (CRHBP), rs634479 (OPRM1), and rs8030107 (NTRK3). Family-based analysis identified a two-SNP haplotype in HTR1B suggestive for association with the cortisol response (rs6296, rs11568817). Allelic TDTs identified rs7897947 (NFKB2) as potentially related to cortisol response.
Conclusions:
Findings provide preliminary evidence for genes potentially important in cortisol response to an acute stressor in children in the serotonin, dopamine, and brain-derived neurotrophic factor pathways, the hypothalamic–pituitary–adrenal axis, and the inflammatory response. Combined with analyses of related phenotypes and clinical data, these results could help identify patients at increased risk of adverse responses to painful medical procedures who might benefit from tailored interventions.
Details
- Title: Subtitle
- Genetic Variants and the Cortisol Response in Children: An Exploratory Study
- Creators
- Anne L Ersig - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USADebra L Schutte - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USAJennifer Standley - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USAElizabeth J Leslie - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USABridget Zimmerman - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USAKirsten Hanrahan - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USAJeffrey C Murray - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USAAnn Marie McCarthy - School of Nursing, University of Wisconsin–Madison, Madison, WI, USA College of Nursing, Wayne State University, Detroit, MI, USA College of Medicine, The University of Iowa, Iowa, IA, USA School of Medicine, Emory University, Atlanta, GA, USA College of Public Health, The University of Iowa, Iowa, IA, USA University of Iowa Hospitals and Clinics, Iowa, IA, USA College of Nursing, The University of Iowa, Iowa, IA, USA
- Resource Type
- Journal article
- Publication Details
- Biological research for nursing, Vol.21(2), pp.157-165
- DOI
- 10.1177/1099800419826315
- PMID
- 30700110
- PMCID
- PMC6700893
- NLM abbreviation
- Biol Res Nurs
- ISSN
- 1099-8004
- eISSN
- 1552-4175
- Publisher
- SAGE Publications
- Grant note
- 5R01NR005269-08 / ;
- Language
- English
- Date published
- 03/2019
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Dental Research; Community and Behavioral Health
- Record Identifier
- 9984214798202771
Metrics
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