Genetic Variation for Mitochondrial Function in the New Zealand Freshwater Snail Potamopyrgus antipodarum

Joel Sharbrough; Jennifer L Cruise; Megan Beetch; Nicole M Enright; Maurine Neiman

doi:10.1093/jhered/esx041

Back

Genetic Variation for Mitochondrial Function in the New Zealand Freshwater Snail Potamopyrgus antipodarum

Journal article

Open access

Peer reviewed

Genetic Variation for Mitochondrial Function in the New Zealand Freshwater Snail Potamopyrgus antipodarum

Joel Sharbrough, Jennifer L Cruise, Megan Beetch, Nicole M Enright and Maurine Neiman

The Journal of heredity, Vol.108(7), pp.759-768

10/30/2017

DOI: 10.1093/jhered/esx041

PMID: 28460111

Files and links (1)

url

https://doi.org/10.1093/jhered/esx041View

Published (Version of record) Open Access

Abstract

The proteins responsible for mitochondrial function are encoded by 2 different genomes with distinct inheritance regimes, rendering rigorous inference of genotype-phenotype connections intractable for all but a few model systems. Asexual organisms provide a powerful means to address these challenges because offspring produced without recombination inherit both nuclear and mitochondrial genomes from a single parent. As such, these offspring inherit mitonuclear genotypes that are identical to the mitonuclear genotypes of their parents and siblings but different from those of other asexual lineages. Here, we compared mitochondrial function across distinct asexual lineages of Potamopyrgus antipodarum, a New Zealand freshwater snail model for understanding the evolutionary consequences of asexuality. Our analyses revealed substantial phenotypic variation across asexual lineages at 3 levels of biological organization: mitogenomic, organellar, and organismal. These data demonstrate that different asexual lineages have different mitochondrial function phenotypes, likely reflecting heritable variation (i.e., the raw material for evolution) for mitochondrial function in P. antipodarum. The discovery of this variation combined with the methods developed here sets the stage to use P. antipodarum to study central evolutionary questions involving mitochondrial function, including whether mitochondrial mutation accumulation influences the maintenance of sexual reproduction in natural populations.

Animals

DNA, Mitochondrial - genetics

Genetic Variation

Genome, Mitochondrial

Hot Temperature

Mitochondria - genetics

Mitochondria - physiology

New Zealand

Oxygen Consumption

Phenotype

Snails - genetics

Stress, Physiological

Details

Title: Subtitle: Genetic Variation for Mitochondrial Function in the New Zealand Freshwater Snail Potamopyrgus antipodarum
Creators: Joel Sharbrough - Department of Biology, Colorado State University, Fort Collins, CO
Jennifer L Cruise - Department of Biology, University of St. Thomas, Saint Paul, MN
Megan Beetch - Department of Biology, University of St. Thomas, Saint Paul, MN
Nicole M Enright - Department of Biology, University of Iowa, Iowa City, IA
Maurine Neiman - Department of Biology, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: The Journal of heredity, Vol.108(7), pp.759-768
DOI: 10.1093/jhered/esx041
PMID: 28460111
NLM abbreviation: J Hered
ISSN: 0022-1503
eISSN: 1465-7333
Grant note: DOI: 10.13039/100000001, name: National Science Foundation, award: MCB—1122176, DEB—1310825
Language: English
Date published: 10/30/2017
Academic Unit: Office Of The Provost; Gender, Women's and Sexuality Studies; Biology
Record Identifier: 9984217530502771

Metrics

10 Record Views

8 Times Cited - Web of Science