Genetic Variation of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam Shows Both Species-Specific and Spatiotemporal Associations

Margaret Carrel; Xiu-Feng Wan; Tung Nguyen; Michael Emch

doi:10.1637/9785-051811-Reg.1

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Genetic Variation of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam Shows Both Species-Specific and Spatiotemporal Associations

Journal article

Peer reviewed

Genetic Variation of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam Shows Both Species-Specific and Spatiotemporal Associations

Margaret Carrel, Xiu-Feng Wan, Tung Nguyen and Michael Emch

Avian diseases, Vol.55(4), pp.659-666

12/2011

DOI: 10.1637/9785-051811-Reg.1

PMCID: PMC3841065

PMID: 22312987

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Abstract

Domestic poultry act as a reservoir for persistent H5N1 endemicity in Vietnam, and the circulation of poultry flocks across farms and to market is thought to drive the spatial movement and evolution of avian influenza viruses. Using a dataset of complete or nearly full genomic sequences from highly pathogenic H5N1 avian influenza viruses collected in domestic poultry in Vietnam from 2003 to 2007, we explore potential differences in genetic characteristics according to species of isolation and the spatiotemporal characteristics of the viruses. Clustering algorithms and ANOVA indicate that H5N1 viruses in Vietnam show differences in the amount of genetic change that chicken viruses experience as compared to duck viruses, with duck viruses showing higher rates of molecular evolution on all eight of influenza's gene segments. There also exist distinct patterns of genetic differentiation according to the year in which they were isolated. These findings suggest that genetic evolution of avian influenza viruses is continuous through time but could also be mediated by the species in which the viruses occur, information that has implications for prevention efforts.

Ecology

analysis of variance

cluster analysis

genetic differentiation

H5N1 avian influenza

poultry

Regular s

Details

Title: Subtitle: Genetic Variation of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam Shows Both Species-Specific and Spatiotemporal Associations
Creators: Margaret Carrel - University of Iowa
Xiu-Feng Wan - Mississippi State University
Tung Nguyen - Department of Animal Health
Michael Emch - University of North Carolina at Chapel Hill
Resource Type: Journal article
Publication Details: Avian diseases, Vol.55(4), pp.659-666
DOI: 10.1637/9785-051811-Reg.1
PMID: 22312987
PMCID: PMC3841065
NLM abbreviation: Avian Dis
ISSN: 0005-2086
eISSN: 1938-4351
Publisher: American Association of Avian Pathologists
Number of pages: 8
Alternative title: Genetic variation of H5N1 in Vietnamese chickens and ducks
Language: English
Date published: 12/2011
Academic Unit: Epidemiology; Interdisciplinary Programs; Geographical and Sustainability Sciences; Internal Medicine
Record Identifier: 9984259384502771

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