Genetic admixture in Brazilians exposed to infection with Leishmania chagasi

Nicholas A Ettinger; Priya Duggal; Regina F S Braz; Eliana T Nascimento; Terri H Beaty; Selma M B Jeronimo; Richard D Pearson; Jenefer M Blackwell; Lina Moreno; Mary E Wilson

doi:10.1111/j.1469-1809.2009.00510.x

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Genetic admixture in Brazilians exposed to infection with Leishmania chagasi

Journal article

Peer reviewed

Genetic admixture in Brazilians exposed to infection with Leishmania chagasi

Nicholas A Ettinger, Priya Duggal, Regina F S Braz, Eliana T Nascimento, Terri H Beaty, Selma M B Jeronimo, Richard D Pearson, Jenefer M Blackwell, Lina Moreno and Mary E Wilson

Annals of human genetics, Vol.73(Pt 3), pp.304-313

05/2009

DOI: 10.1111/j.1469-1809.2009.00510.x

PMCID: PMC2731584

PMID: 19397557

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Abstract

Visceral leishmaniasis (VL) in northeast Brazil is a disease caused by infection with the protozoan Leishmania chagasi. Infection leads to variable clinical outcomes ranging from asymptomatic infection to potentially fatal disease. Prior studies suggest the genetic background of the host contributes to the development of different outcomes after infection, although it is not known if ancestral background itself influences outcomes. VL is endemic in peri-urban areas around the city of Natal in northeast Brazil. The population of northeast Brazil is a mixture of distinct racial and ethnic groups. We hypothesized that some sub-populations may be more susceptible than others to develop different clinical outcomes after L. chagasi infection. Using microsatellite markers, we examined whether admixture of the population as a whole, or markers likely inherited from a distinct ethnic background, differed between individuals with VL, individuals with an asymptomatic infection, or individuals with no infection. There was no apparent significant difference in overall population admixture proportions among the three clinical phenotype groups. However, one marker on Chr. 22 displayed evidence of excess ancestry from putative ancestral populations among different clinical phenotypes, suggesting this region may contain genes determining the course of L. chagasi infection.

Animals

Leishmaniasis, Visceral - ethnology

Humans

Brazil - ethnology

Leishmaniasis, Visceral - genetics

Leishmania - physiology

Leishmaniasis, Visceral - parasitology

Microsatellite Repeats

Details

Title: Subtitle: Genetic admixture in Brazilians exposed to infection with Leishmania chagasi
Creators: Nicholas A Ettinger - Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa; Iowa City, IA 52242, USA
Priya Duggal
Regina F S Braz
Eliana T Nascimento
Terri H Beaty
Selma M B Jeronimo
Richard D Pearson
Jenefer M Blackwell
Lina Moreno
Mary E Wilson
Resource Type: Journal article
Publication Details: Annals of human genetics, Vol.73(Pt 3), pp.304-313
DOI: 10.1111/j.1469-1809.2009.00510.x
PMID: 19397557
PMCID: PMC2731584
NLM abbreviation: Ann Hum Genet
ISSN: 0003-4800
eISSN: 1469-1809
Publisher: England
Grant note: T32 AI007511-13 / NIAID NIH HHS AI048822 / NIAID NIH HHS R01 AI045540-06 / NIAID NIH HHS T32 GM007337 / NIGMS NIH HHS P50 AI030639-17 / NIAID NIH HHS T32 AI07511 / NIAID NIH HHS R01 AI048822 / NIAID NIH HHS AI045540 / NIAID NIH HHS P50 AI030639-170015 / NIAID NIH HHS P50 AI-30639 / NIAID NIH HHS R01 AI045540 / NIAID NIH HHS T32 AI007511 / NIAID NIH HHS Intramural NIH HHS R01 AI045540-07 / NIAID NIH HHS R01 AI067874-03 / NIAID NIH HHS P50 AI030639-16 / NIAID NIH HHS R01 AI067874 / NIAID NIH HHS R01 AI048822-05 / NIAID NIH HHS AI067874 / NIAID NIH HHS R01 AI076233 / NIAID NIH HHS P50 AI030639 / NIAID NIH HHS
Language: English
Date published: 05/2009
Academic Unit: Orthodontics; Microbiology and Immunology; International Programs; Epidemiology; Craniofacial Anomalies Research Center; Dental Research; Internal Medicine
Record Identifier: 9984001215202771

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