Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study

Rhea Powell; Duncan Davidson; Jasmin Divers; Ani Manichaikul; J Jeffrey Carr; Robert Detrano; Eric A Hoffman; Rui Jiang; Richard A Kronmal; Kiang Liu; Naresh M Punjabi; Eyal Shahar; Karol E Watson; Jerome I Rotter; Kent D Taylor; Stephen S Rich; R Graham Barr

doi:10.1136/thoraxjnl-2012-202116

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Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study

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Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study

Rhea Powell, Duncan Davidson, Jasmin Divers, Ani Manichaikul, J Jeffrey Carr, Robert Detrano, Eric A Hoffman, Rui Jiang, Richard A Kronmal, Kiang Liu, …

Thorax, Vol.68(7), pp.634-642

07/2013

DOI: 10.1136/thoraxjnl-2012-202116

PMID: 23585509

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Abstract

BackgroundCigarette smoking is the major cause of chronic obstructive pulmonary disease and emphysema. Recent studies suggest that susceptibility to cigarette smoke may vary by race/ethnicity; however, they were generally small and relied on self-reported race/ethnicity. Objective To test the hypothesis that relationships of smoking to lung function and per cent emphysema differ by genetic ancestry and self-reported race/ethnicity among Caucasians, African-Americans, Hispanics and Chinese-Americans. Design Cross-sectional population-based study of adults age 45–84 years in the USA. Measurements Principal components of genetic ancestry and continental ancestry estimated from one million genome-wide single nucleotide polymorphisms; pack-years of smoking; spirometry measured for 3344 participants; and per cent emphysema on computed tomography for 8224 participants. Results The prevalence of ever-smoking was: Caucasians, 57.6%; African-Americans, 56.4%; Hispanics, 46.7%; and Chinese-Americans, 26.8%. Every 10 pack-years was associated with −0.73% (95% CI −0.90% to −0.56%) decrement in the forced expiratory volume in 1 s to forced vital capacity (FEV1 to FVC) and a 0.23% (95% CI 0.08% to 0.38%) increase in per cent emphysema. There was no evidence that relationships of pack-years to the FEV1 to FVC, airflow obstruction and per cent emphysema varied by genetic ancestry (all p>0.10), self-reported race/ethnicity (all p>0.10) or, among African-Americans, African ancestry. There were small differences in relationships of pack-years to the FEV1 among male Chinese-Americans and to the FEV1 to FVC ratio with African and Native American ancestry among male Hispanics only. Conclusions In this large cohort, there was little to no evidence that the associations of smoking to lung function and per cent emphysema differed by genetic ancestry or self-reported race/ethnicity.

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Title: Subtitle: Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study
Creators: Rhea Powell - Department of Medicine, Columbia University Medical Center, New York, New York, USA
Duncan Davidson - Department of Medicine, Columbia University Medical Center, New York, New York, USA
Jasmin Divers - Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA
Ani Manichaikul - Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA and Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
J Jeffrey Carr - Department of Radiology, Division of Radiological Sciences, Wake-Forest University, Winston-Salem, North Carolina, USA
Robert Detrano - Department of Radiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA
Eric A Hoffman - Department of Radiology, University of Iowa, Iowa City, Iowa, USA
Rui Jiang - Department of Medicine, Columbia University Medical Center, New York, New York, USA
Richard A Kronmal - Department of Biostatistics, University of Washington, Seattle, Washington, USA
Kiang Liu - Department of Preventative Medicine, Northwestern University Medical School, Chicago, Illinois, USA
Naresh M Punjabi - Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Eyal Shahar - Division of Epidemiology and Biostatistics, University of Arizona, Tucson, Arizona, USA
Karol E Watson - Department of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Jerome I Rotter - Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Kent D Taylor - Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Stephen S Rich - Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA and Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA
R Graham Barr - Department of Epidemiology, Columbia University Medical Center, New York, New York, USA
Resource Type: Journal article
Publication Details: Thorax, Vol.68(7), pp.634-642
DOI: 10.1136/thoraxjnl-2012-202116
PMID: 23585509
ISSN: 0040-6376
eISSN: 1468-3296
Language: English
Date published: 07/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984051505502771

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