Journal article
Genetic and Developmental Characterization of Dmca1D, a Calcium Channel α1 Subunit Gene in Drosophila melanogaster
Genetics (Austin), Vol.148(3), pp.1159-1169
03/01/1998
DOI: 10.1093/genetics/148.3.1159
Abstract
Abstract To begin unraveling the functional significance of calcium channel diversity, we identified mutations in Dmca1D, a Drosophila calcium channel α1 subunit cDNA that we recently cloned. These mutations constitute the l(2)35Fa lethal locus, which we rename Dmca1D. A severe allele, Dmca1DX10, truncates the channel after the IV-S4 transmembrane domain. These mutants die as late embryos because they lack vigorous hatching movements. In the weaker allele, Dmca1DAR66, a cysteine in transmembrane domain I-S1 is changed to tyrosine. Dmca1DAR66 embryos hatch but pharate adults have difficulty eclosing. Those that do eclose have difficulty in fluid-filling of the wings. These studies show that this member of the calcium channel α1 subunit gene family plays a nonredundant, vital role in larvae and adults.
Details
- Title: Subtitle
- Genetic and Developmental Characterization of Dmca1D, a Calcium Channel α1 Subunit Gene in Drosophila melanogaster
- Creators
- Daniel F Eberl - Department of Biochemical Pharmacology, The State University of New York at Buffalo, Buffalo, New York 14260-1200, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115Dejian Ren - Department of Biochemical Pharmacology, The State University of New York at Buffalo, Buffalo, New York 14260-1200Guoping Feng - Department of Biochemical Pharmacology, The State University of New York at Buffalo, Buffalo, New York 14260-1200Lori J Lorenz - Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115David Van Vactor - Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115Linda M Hall - Department of Biochemical Pharmacology, The State University of New York at Buffalo, Buffalo, New York 14260-1200
- Resource Type
- Journal article
- Publication Details
- Genetics (Austin), Vol.148(3), pp.1159-1169
- DOI
- 10.1093/genetics/148.3.1159
- ISSN
- 1943-2631
- eISSN
- 1943-2631
- Language
- English
- Date published
- 03/01/1998
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984071769202771
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