Journal article
Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice
Journal of the National Cancer Institute. Monographs, Vol.2008(39), pp.37-40
2008
DOI: 10.1093/jncimonographs/lgn015
PMID: 18648000
Abstract
Peritoneal plasmacytomagenesis in inbred BALB/c mice affords an experimental model system for the study of the mechanism by which naturally occurring Myc (c-myc) translocations collaborate with host susceptibility factors and environmental influences in tumor development. Mouse plasmacytoma is initiated in approximately 80% of cases by a balanced chromosomal T(12;15)(Igh-Myc) translocation that results in a mode of Myc deregulation that renders the survival and outgrowth of the translocation-bearing tumor precursor exquisitely dependent upon factors provided by sustained inflammation (IL-6) and gut flora microbes. Tumor susceptibility genes of BALB/c, such as weak efficiency alleles of genes encoding p16(Ink4a) and Frap (mTOR), are also required for plasmacytoma, although the pathways linking these genes with deregulated Myc and the environment have not yet been elucidated. The findings in mouse plasmacytoma may be relevant for hematopoietic neoplasms in human beings, in which leukemia- and lymphoma-associated chromosomal translocation (LLA-CT) is much more frequent than subsequent neoplasia. Just like T(12;15)-carrying B-lymphocytes and plasma cells in mice, the malignant transformation of LLA-CT-bearing blood cells in humans may be a rare occurrence that requires several genetic and environmental cofactors to take place.
Details
- Title: Subtitle
- Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice
- Creators
- Siegfried Janz - Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bldg 37, Rm 2B10, Bethesda, MD 20892-4256, USA. sj4s@nih.gov
- Resource Type
- Journal article
- Publication Details
- Journal of the National Cancer Institute. Monographs, Vol.2008(39), pp.37-40
- DOI
- 10.1093/jncimonographs/lgn015
- PMID
- 18648000
- NLM abbreviation
- J Natl Cancer Inst Monogr
- ISSN
- 1052-6773
- eISSN
- 1745-6614
- Grant note
- Intramural NIH HHS
- Language
- English
- Date published
- 2008
- Academic Unit
- Pathology
- Record Identifier
- 9984083869802771
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