Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

David B. Chorlian; Madhavi Rangaswamy; Niklas Manz; Jen-Chyong Wang; Danielle Dick; Laura Almasy; Lance Bauer; Kathleen Bucholz; Tatiana Foroud; Victor Hesselbrock; Sun J. Kang; John Kramer; Sam Kuperman; John Nurnberger; John Rice; Marc Schuckit; Jay Tischfield; Howard J. Edenberg; Alison Goate; Laura Bierut; Bernice Porjesz

doi:10.1007/s10519-013-9604-z

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Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

Journal article

Peer reviewed

Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults

David B. Chorlian, Madhavi Rangaswamy, Niklas Manz, Jen-Chyong Wang, Danielle Dick, Laura Almasy, Lance Bauer, Kathleen Bucholz, Tatiana Foroud, Victor Hesselbrock, …

Behavior genetics, Vol.43(5), pp.386-401

08/21/2013

DOI: 10.1007/s10519-013-9604-z

PMCID: PMC4110722

PMID: 23963516

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https://soar.suny.edu/bitstream/20.500.12648/8150/1/nihms518630.pdfView

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Abstract

Discrete time survival analysis (DTSA) was used to assess the age-specific association of event related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2938 adolescents and young adults ages 12 to 25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associations were concentrated in those subjects who at some time took an illicit drug. These results are consistent with studies which associate greater rates of alcohol dependence among those who begin drinking at an early age. The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.

adolescents

alcoholism

CHRM2

ERO

genetics

survival analysis

Details

Title: Subtitle: Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults
Creators: David B. Chorlian - SUNY Downstate Health Sciences University
Madhavi Rangaswamy - SUNY Downstate Health Sciences University
Niklas Manz - SUNY Downstate Health Sciences University
Jen-Chyong Wang - Washington University in St. Louis
Danielle Dick - Virginia Commonwealth University
Laura Almasy - Texas Biomedical Research Institute
Lance Bauer - University of Connecticut
Kathleen Bucholz - Washington University in St. Louis
Tatiana Foroud - Indiana University
Victor Hesselbrock - University of Connecticut
Sun J. Kang - SUNY Downstate Health Sciences University
John Kramer - University of Iowa
Sam Kuperman - University of Iowa
John Nurnberger - Indiana University
John Rice - Washington University in St. Louis
Marc Schuckit - University of California San Diego
Jay Tischfield - Rutgers, The State University of New Jersey
Howard J. Edenberg - Indiana University
Alison Goate - Washington University in St. Louis
Laura Bierut - Washington University in St. Louis
Bernice Porjesz - SUNY Downstate Health Sciences University
Resource Type: Journal article
Publication Details: Behavior genetics, Vol.43(5), pp.386-401
DOI: 10.1007/s10519-013-9604-z
PMID: 23963516
PMCID: PMC4110722
NLM abbreviation: Behav Genet
ISSN: 0001-8244
eISSN: 1573-3297
Language: English
Date published: 08/21/2013
Academic Unit: Psychiatry
Record Identifier: 9984293754702771

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