Journal article
Genetic and physical maps of human chromosome 4 based on dinucleotide repeats
Genomics (San Diego, Calif.), Vol.14(2), pp.209-219
1992
DOI: 10.1016/S0888-7543(05)80208-3
PMID: 1427835
Abstract
Characterization of inherited variations within tandem arrays of dinucleotide repeats has substantially advanced the construction of genetic maps using linkage approaches over the last several years. Using a backbone of 10 newly identified microsatellite repeats on human chromosome 4 and 6 previously identified short tandem repeat element polymorphisms, we have constructed several genetic maps and a physical map of human chromosome 4. The genetic and physical maps are in complete concordance with each other. The genetic maps include a 15-locus microsatellite-based linkage map, a framework map of high support incorporating a total of 39 independent loci, a 25-locus high-heterozy-gosity, easily and index map, and a gene-based comprehensive map that provides the best genetic location for 35 genes mapped to chromosome 4. The 16 microsatellite markers are each localized to one of nine regions of chromosome 4, delineated by a panel of somatic cell hybrids. These results demonstrate the utility of PCR-based repeat elements for the construction of genetic maps and provide a valuable resource for continued high-resolution mapping of chromosome 4 and of genetic disorders to this chromosome.
Details
- Title: Subtitle
- Genetic and physical maps of human chromosome 4 based on dinucleotide repeats
- Creators
- K.A Mills - University of Iowa Hospitals, Department of Pediatrics, Iowa City, Iowa 52242, USAK.H Buetow - Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USAY Xu - University of Iowa Hospitals, Department of Pediatrics, Iowa City, Iowa 52242, USAJ.L Weber - Marshfield Medical Research Foundation, 1000 North Oak Avenue, Marshfield, Wisconsin 54449, USAM.R Altherr - Department of Biological Chemistry, University of California, Irvine, California 92717, USAJ.J Wasmuth - Department of Biological Chemistry, University of California, Irvine, California 92717, USAJ.C Murray - University of Iowa Hospitals, Department of Pediatrics, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Genomics (San Diego, Calif.), Vol.14(2), pp.209-219
- DOI
- 10.1016/S0888-7543(05)80208-3
- PMID
- 1427835
- NLM abbreviation
- Genomics
- ISSN
- 0888-7543
- eISSN
- 1089-8646
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1992
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025670002771
Metrics
17 Record Views