Journal article
Genetic approaches to the study of synaptic plasticity and memory storage
CNS spectrums, Vol.8(8), pp.597-610
08/2003
DOI: 10.1017/S1092852900018873
PMID: 12907923
Abstract
Long-term memory is believed to depend on long-lasting changes in the strength of synaptic transmission known as synaptic plasticity. Understanding the molecular mechanisms of long-term synaptic plasticity is one of the principle goals of neuroscience. Among the most powerful tools being brought to bear on this question are genetically modified mice with changes in the expression or biological activity of genes thought to contribute to these processes. This article reviews how strains of mice with alterations in the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-response element-binding protein signaling pathway have advanced our understanding of the biological basis of learning and memory.
Details
- Title: Subtitle
- Genetic approaches to the study of synaptic plasticity and memory storage
- Creators
- Michael P Kaplan - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA. abele@sas.upenn.eduTed Abel
- Resource Type
- Journal article
- Publication Details
- CNS spectrums, Vol.8(8), pp.597-610
- Publisher
- United States
- DOI
- 10.1017/S1092852900018873
- PMID
- 12907923
- ISSN
- 1092-8529
- eISSN
- 2165-6509
- Grant note
- T32 MH014654 / NIMH NIH HHS R01 AG18199 / NIA NIH HHS HD26979 / NICHD NIH HHS R01 MH60244 / NIMH NIH HHS
- Language
- English
- Date published
- 08/2003
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065832502771
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