Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates

K K Ryckman; J M Dagle; K Kelsey; A M Momany; J C Murray

doi:10.1038/jp.2011.104

Back

Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates

Journal article

Open access

Peer reviewed

Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates

K K Ryckman, J M Dagle, K Kelsey, A M Momany and J C Murray

Journal of perinatology, Vol.32(5), pp.349-355

05/2012

DOI: 10.1038/jp.2011.104

PMCID: PMC3370386

PMID: 21960125

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/3370386View

Open Access

Abstract

To replicate genetic associations with respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in genes related to surfactant deficiency, inflammation and infection, and the renin-angiotensin system. We examined eight candidate genes for associations with RDS and BPD in 433 preterm birth (PTB-<37 weeks) infants (251 with RDS and 134 with BPD). Both case-control and family-based analyses were performed in preterm (<37 weeks) and very preterm birth (VPTB-<32 weeks) infants. We replicated a previous finding that rs1923537, a marker downstream of surfactant protein D (SFTPD) is associated with RDS in VPTB infants in that the T allele was overtransmitted from parents to offspring with RDS (P=8.4 × 10(-3)). We also observed the A allele of rs4351 in the angiotensin-converting enzyme (ACE) gene was overtransmitted from parents to VPTB offspring with BPD (P=9.8 × 10(-3)). These results give further insight into the genetic risk factors for complex neonatal respiratory diseases and provide more evidence of the importance of SFTPD and ACE in the etiology of RDS and BPD, respectively.

Genetic Testing

Prognosis

Humans

Respiratory Distress Syndrome, Newborn - epidemiology

Male

Neonatal Screening

Incidence

Bronchopulmonary Dysplasia - epidemiology

Peptidyl-Dipeptidase A - genetics

Bronchopulmonary Dysplasia - genetics

Intensive Care Units, Neonatal

DNA - analysis

Gene Expression Regulation, Developmental

Respiratory Distress Syndrome, Newborn - genetics

Female

Retrospective Studies

Infant, Newborn

Genetic Predisposition to Disease

Respiratory Distress Syndrome, Newborn - diagnosis

Risk Assessment

Renin-Angiotensin System - genetics

Renin-Angiotensin System - physiology

Survival Rate

Gestational Age

Pulmonary Surfactant-Associated Protein D - genetics

DNA - genetics

Pregnancy

Bronchopulmonary Dysplasia - diagnosis

Infant, Premature

Alleles

Sex Distribution

Polymorphism, Single Nucleotide

Cohort Studies

Details

Title: Subtitle: Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates
Creators: K K Ryckman - Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
J M Dagle
K Kelsey
A M Momany
J C Murray
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.32(5), pp.349-355
DOI: 10.1038/jp.2011.104
PMID: 21960125
PMCID: PMC3370386
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Publisher: United States
Grant note: R01 HD057192 / NICHD NIH HHS R01 HD-57192 / NICHD NIH HHS 5T32 HL 007638-24 / NHLBI NIH HHS R01 HD052953 / NICHD NIH HHS R01 HD-52953 / NICHD NIH HHS T32 HL007638 / NHLBI NIH HHS
Language: English
Date published: 05/2012
Academic Unit: Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9983995127702771

Metrics

19 Record Views

33 Times Cited - Web of Science

See more details