Journal article
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Nature communications, Vol.11(1), pp.4796-4796
09/22/2020
DOI: 10.1038/s41467-020-18367-y
PMCID: PMC7508833
PMID: 32963231
Abstract
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
Details
- Title: Subtitle
- Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
- Creators
- Edith Hofer - Medical University of GrazGennady V Roshchupkin - Erasmus University RotterdamHieab H H Adams - Erasmus University RotterdamMaria J Knol - Erasmus University RotterdamHonghuang Lin - Boston UniversityShuo Li - Boston UniversityHabil Zare - The University of Texas Health Science Center at San AntonioShahzad Ahmad - Erasmus University RotterdamNicola J Armstrong - Murdoch UniversityClaudia L Satizabal - Boston UniversityManon Bernard - Hospital for Sick Children, Toronto, ON, CanadaJoshua C Bis - University of WashingtonNathan A Gillespie - QIMR Berghofer Medical Research InstituteMichelle Luciano - University of EdinburghAniket Mishra - Université de BordeauxMarkus Scholz - LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, GermanyAlexander Teumer - Institute for Community Medicine, University Medicine Greifswald, Greifswald, GermanyRui Xia - Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USAXueqiu Jian - Institute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USAThomas H Mosley - University of Mississippi Medical CenterYasaman Saba - Medical University of GrazLukas Pirpamer - Medical University of GrazStephan Seiler - Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USAJames T Becker - University of PittsburghOwen Carmichael - Pennington Biomedical Research CenterJerome I Rotter - The Lundquist InstituteBruce M Psaty - University of WashingtonOscar L Lopez - University of PittsburghNajaf Amin - Department of Epidemiology, Erasmus MC, Rotterdam, The NetherlandsSven J van der Lee - Department of Epidemiology, Erasmus MC, Rotterdam, The NetherlandsQiong Yang - Boston UniversityJayandra J Himali - Boston UniversityPauline Maillard - Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USAAlexa S Beiser - Boston University School of MedicineCharles DeCarli - Department of Neurology and Center for Neuroscience, University of California at Davis, Sacramento, CA, USASherif Karama - McGill UniversityLindsay Lewis - McGill UniversityMat Harris - University of EdinburghMark E Bastin - University of EdinburghIan J Deary - University of EdinburghA Veronica Witte - Institute of Cytology and Preventive OncologyFrauke Beyer - Institute of Cytology and Preventive OncologyMarkus Loeffler - LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, GermanyKaren A Mather - Neuroscience Research AustraliaPeter R Schofield - School of Medical Sciences, University of New South Wales, Sydney, AustraliaAnbupalam Thalamuthu - Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaJohn B Kwok - The University of SydneyMargaret J Wright - The University of QueenslandDavid Ames - The University of MelbourneJulian Trollor - Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, AustraliaJiyang Jiang - Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaHenry Brodaty - Dementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, AustraliaWei Wen - Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaMeike W Vernooij - Department of Epidemiology, Erasmus MC, Rotterdam, The NetherlandsAlbert Hofman - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USAAndré G Uitterlinden - Erasmus MCWiro J Niessen - Delft University of TechnologyKatharina Wittfeld - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, GermanyRobin Bülow - Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, GermanyUwe Völker - Universitätsmedizin GreifswaldZdenka Pausova - University of TorontoG. Bruce Pike - University of CalgarySophie Maingault - Université de BordeauxFabrice Crivello - Université de BordeauxChristophe Tzourio - Centre Hospitalier Universitaire de BordeauxPhilippe Amouyel - Department of Public Health, Lille University Hospital, Lille, FranceBernard Mazoyer - Université de BordeauxMichael C Neale - Virginia Commonwealth UniversityCarol E Franz - University of California San DiegoMichael J Lyons - Boston UniversityMatthew S Panizzon - University of California San DiegoOle A Andreassen - University of OsloAnders M Dale - University of California San DiegoMark Logue - Boston UniversityKatrina L Grasby - QIMR Berghofer Medical Research InstituteNeda Jahanshad - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAJodie N Painter - QIMR Berghofer Medical Research InstituteLucía Colodro-Conde - QIMR Berghofer Medical Research InstituteJanita Bralten - Radboud University NijmegenDerrek P Hibar - University of Southern CaliforniaPenelope A Lind - QIMR Berghofer Medical Research InstituteFabrizio Pizzagalli - Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAJason L Stein - University of North Carolina at Chapel HillPaul M Thompson - University of Southern CaliforniaSarah E Medland - QIMR Berghofer Medical Research InstitutePerminder S Sachdev - Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, AustraliaWilliam S Kremen - University of California San DiegoJoanna M Wardlaw - University of EdinburghArno Villringer - University Hospital LeipzigCornelia M van Duijn - University of OxfordHans J Grabe - Universität GreifswaldWilliam T Longstreth Jr - University of WashingtonMyriam Fornage - The University of Texas Health Science Center at HoustonTomas Paus - University of TorontoStephanie Debette - Université de BordeauxM Arfan Ikram - Erasmus University RotterdamHelena Schmidt - Medical University of GrazReinhold Schmidt - Medical University of GrazSudha Seshadri - Boston UniversityENIGMA consortium
- Contributors
- Beng Choon Ho (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.11(1), pp.4796-4796
- DOI
- 10.1038/s41467-020-18367-y
- PMID
- 32963231
- PMCID
- PMC7508833
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Grant note
- MR/M013111/1 / Medical Research Council HHSN268201100007C / NHLBI NIH HHS U01 AG049505 / NIA NIH HHS UL1 TR001881 / NCATS NIH HHS TMH109788 / CIHR R01 AG049607 / NIA NIH HHS MC_QA137853 / Medical Research Council R01 HL103612 / NHLBI NIH HHS R01 MH117601 / NIMH NIH HHS HHSN268201100011C / NHLBI NIH HHS R01 MH116147 / NIMH NIH HHS HHSN268201100005C / NHLBI NIH HHS RF1 AG051710 / NIA NIH HHS R01 AG059874 / NIA NIH HHS HHSN268201100010C / NHLBI NIH HHS 8200 / Medical Research Council R01 NS087541 / NINDS NIH HHS U54 EB020403 / NIBIB NIH HHS N02 HL64278 / NHLBI NIH HHS MR/M01311/1 / Medical Research Council R01 AG008122 / NIA NIH HHS HHSN268201500001I / NHLBI NIH HHS G0700704 / Medical Research Council N01HC25195 / NHLBI NIH HHS R01 AG033040 / NIA NIH HHS S10 OD023696 / NIH HHS MC_PC_17228 / Medical Research Council N01HC85081 / NHLBI NIH HHS RF1 AG041915 / NIA NIH HHS MR/R024065/1 / Medical Research Council R01 AG054076 / NIA NIH HHS R01 HL087652 / NHLBI NIH HHS N01HC85086 / NHLBI NIH HHS U01 HL080295 / NHLBI NIH HHS R01 AG022381 / NIA NIH HHS 75N92019D00031 / NHLBI NIH HHS R01 HL120393 / NHLBI NIH HHS R01 AG050595 / NIA NIH HHS N01HC85083 / NHLBI NIH HHS R01 NS017950 / NINDS NIH HHS NRF86678 / CIHR HHSN268201100012C / NHLBI NIH HHS R01 AG033193 / NIA NIH HHS N01HC85080 / NHLBI NIH HHS R01 AG023629 / NIA NIH HHS HHSN268201800001C / NHLBI NIH HHS HHSN268201100006C / NHLBI NIH HHS P30 AG010129 / NIA NIH HHS P41 EB015922 / NIBIB NIH HHS R01 EB015611 / NIBIB NIH HHS HHSN268201200036C / NHLBI NIH HHS RC2 HL102419 / NHLBI NIH HHS R01 AG016495 / NIA NIH HHS N01HC55222 / NHLBI NIH HHS U01 HL130114 / NHLBI NIH HHS HHSN268200800007C / NHLBI NIH HHS N01HC85082 / NHLBI NIH HHS P01 AG026572 / NIA NIH HHS HHSN268201100008C / NHLBI NIH HHS NET54015 / CIHR G0700704/84698 / Medical Research Council G1001401 / Medical Research Council R01 HL105756 / NHLBI NIH HHS G1001245 / Medical Research Council MR/K026992/1 / Medical Research Council BB/F019394/1 / Biotechnology and Biological Sciences Research Council HHSN268201100009C / NHLBI NIH HHS N01HC85079 / NHLBI NIH HHS MR/N027558/1 / Medical Research Council G0701120 / Medical Research Council
- Language
- English
- Date published
- 09/22/2020
- Academic Unit
- Psychiatry
- Record Identifier
- 9984280877402771
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