Journal article
Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS)
Investigative ophthalmology & visual science, Vol.55(1), pp.587-599
01/29/2014
DOI: 10.1167/iovs.13-13216
PMCID: PMC3908680
PMID: 24346170
Abstract
We tested variants in genes related to lutein and zeaxanthin status for association with age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS). Of 2005 CAREDS participants, 1663 were graded for AMD from fundus photography and genotyped for 424 single nucleotide polymorphisms (SNPs) from 24 candidate genes for carotenoid status. Of 337 AMD cases 91% had early or intermediate AMD. The SNPs were tested individually for association with AMD using logistic regression. A carotenoid-related genetic risk model was built using backward selection and compared to existing AMD risk factors using the area under the receiver operating characteristic curve (AUC). A total of 24 variants from five genes (BCMO1, BCO2, NPCL1L1, ABCG8, and FADS2) not previously related to AMD and four genes related to AMD in previous studies (SCARB1, ABCA1, APOE, and ALDH3A2) were associated independently with AMD, after adjusting for age and ancestry. Variants in all genes (not always the identical SNPs) were associated with lutein and zeaxanthin in serum and/or macula, in this or other samples, except for BCO2 and FADS2. A genetic risk score including nine variants significantly (P = 0.002) discriminated between AMD cases and controls beyond age, smoking, CFH Y402H, and ARMS2 A69S. The odds ratio (95% confidence interval) for AMD among women in the highest versus lowest quintile for the risk score was 3.1 (2.0-4.9). Variants in genes related to lutein and zeaxanthin status were associated with AMD in CAREDS, adding to the body of evidence supporting a protective role of lutein and zeaxanthin in risk of AMD.
Details
- Title: Subtitle
- Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS)
- Creators
- Kristin J Meyers - University of Wisconsin–MadisonJulie A MaresRobert P Igo JrBarbara TruittZhe LiuAmy E MillenMichael L Klein - Oregon Health & Science UniversityElizabeth J JohnsonCorinne D EngelmanChitra K KarkiBarbara BlodiKaren GehrsLesley TinkerRobert WallaceJennifer RobinsonErin S LeBlancGloria SartoPaul S BernsteinJohn Paul SanGiovanniSudha K Iyengar
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.55(1), pp.587-599
- DOI
- 10.1167/iovs.13-13216
- PMID
- 24346170
- PMCID
- PMC3908680
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Publisher
- United States
- Grant note
- 24152 / PHS HHS R01 EY021532 / NEI NIH HHS EY016886 / NEI NIH HHS 32108-9 / PHS HHS R01 EY016886 / NEI NIH HHS EY013018 / NEI NIH HHS 32105-6 / PHS HHS 32122 / PHS HHS N01 WH22110 / WHI NIH HHS 32111-13 / PHS HHS R01 EY011600 / NEI NIH HHS 32115 / PHS HHS 42129-32 / PHS HHS 44221 / PHS HHS U10 EY013018 / NEI NIH HHS 32100-2 / PHS HHS 42107-26 / PHS HHS N01 WH022110 / WHI NIH HHS 32118-32119 / PHS HHS
- Language
- English
- Date published
- 01/29/2014
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980071902771
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