Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations

Mengying Li; Mohammad L Rahman; Jing Wu; Ming Ding; Jorge E Chavarro; Yuan Lin; Sylvia H Ley; Wei Bao; Louise G Grunnet; Stefanie N Hinkle; Anne Cathrine B Thuesen; Edwina Yeung; Robert E Gore-Langton; Seth Sherman; Line Hjort; Freja Bach Kampmann; Anne Ahrendt Bjerregaard; Peter Damm; Fasil Tekola-Ayele; Aiyi Liu; James L Mills; Allan Vaag; Sjurdur F Olsen; Frank B Hu; Cuilin Zhang

doi:10.1136/bmjdrc-2019-000850

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Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations

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Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations

Mengying Li, Mohammad L Rahman, Jing Wu, Ming Ding, Jorge E Chavarro, Yuan Lin, Sylvia H Ley, Wei Bao, Louise G Grunnet, Stefanie N Hinkle, …

BMJ open diabetes research & care, Vol.8(1), p.e000850

02/13/2020

DOI: 10.1136/bmjdrc-2019-000850

PMCID: PMC7039588

PMID: 31958311

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Abstract

ObjectiveWomen with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D.Research design and methodsThis cohort study included 2434 white women with a history of GDM from the Nurses’ Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM.ResultsWomen on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI <median) than better dietary quality (AHEI ≥median), although the interaction was not significant. For example, in NHSII, the RRs across increasing quartiles of GRS were 1.00, 0.99, 1.51 and 1.29 (p trend=0.06) among women with poorer dietary quality and 1.00, 0.83, 0.81 and 0.94 (p trend=0.79) among women with better dietary quality (p interaction=0.11).ConclusionsAmong white women with a history of GDM, higher GRS for T2D was associated with an increased risk of T2D.

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Title: Subtitle: Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations
Creators: Mengying Li - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Mohammad L Rahman - Harvard Pilgrim Health Care
Jing Wu - Glotech (United States)
Ming Ding - Harvard University
Jorge E Chavarro - Brigham and Women's Hospital
Yuan Lin - Indiana University
Sylvia H Ley - Tulane University
Wei Bao - University of Iowa
Louise G Grunnet - Rigshospitalet
Stefanie N Hinkle - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Anne Cathrine B Thuesen - Novo Nordisk Foundation
Edwina Yeung - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Robert E Gore-Langton - Emmes (United States)
Seth Sherman - Emmes (United States)
Line Hjort - Rigshospitalet
Freja Bach Kampmann - Technical University of Denmark
Anne Ahrendt Bjerregaard - Statens Serum Institut
Peter Damm - Rigshospitalet
Fasil Tekola-Ayele - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Aiyi Liu - Eunice Kennedy Shriver National Institute of Child Health and Human Development
James L Mills - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Allan Vaag - AstraZeneca (Brazil)
Sjurdur F Olsen - Statens Serum Institut
Frank B Hu - Brigham and Women's Hospital
Cuilin Zhang - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Resource Type: Journal article
Publication Details: BMJ open diabetes research & care, Vol.8(1), p.e000850
DOI: 10.1136/bmjdrc-2019-000850
PMID: 31958311
PMCID: PMC7039588
NLM abbreviation: BMJ Open Diabetes Res Care
ISSN: 2052-4897
eISSN: 2052-4897
Grant note: name: EU, award: FP7-289346-EarlyNutrition; DOI: 10.13039/100012774, name: Innovationsfonden, award: 09-067124, 11-115923; DOI: 10.13039/501100000724, name: Health Foundation, award: 11/263-96; DOI: 10.13039/100000002, name: National Institutes of Health, award: HHSN275201000020C, R01 CA50385, R01 CA67262, UM1 CA176726; name: March of Dimes Birth Defects Foundation, award: 6-FY-96-0240, 6-FY00-407, 6-FY97-0521, 6-FY97-0553; name: Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, award: HHSN275201000020C, HHSN275201300026I, HHSN275201500003C, HSN275201100002I; DOI: 10.13039/100002129, name: Heart Foundation, award: 96-2-4-83-22450
Language: English
Date published: 02/13/2020
Academic Unit: Epidemiology
Record Identifier: 9984364538902771

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