Journal article
Genetic influences on cognitive endophenotypes in schizophrenia
Schizophrenia research, Vol.156(1), pp.71-75
06/01/2014
DOI: 10.1016/j.schres.2014.03.022
PMCID: PMC4699552
PMID: 24768440
Abstract
Background: Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research.
Methods: The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleotide polymorphisms identified in recent risk studies (genetic risk score). The impact of these genetic factors, and their interaction, was examined on cognitive endophenotypes defined by principal component analysis (PCA) in a multi-center sample of 50 patients with schizophrenia and 86 controls. PCA was used to identify three different types of executive function (EF: planning, fluency, and inhibition), and in separate analyses, a measure general cognitive ability (GCA).
Results: Cognitive deficits were prominent among individuals with schizophrenia, but no group differences were evident for either genetic factor. Among patients the deletion burden measures predicted cognitive deficits across the three EF components and GCA. Further, an interaction was noted between the two genetic factors for both EF and GCA and the observed patterns of interaction suggested antagonistic epistasis. In general, the set of genetic interactions examined predicted a substantial portion of variance in these cognitive endophenotypes.
Limitations: Though adequately powered, our sample size is small for a genetic study.
Conclusions: These results draw attention to genetic interactions and the possibility that genetic influences on cognition differ in patients and controls. (C) 2014 Elsevier B. V. All rights reserved.
Details
- Title: Subtitle
- Genetic influences on cognitive endophenotypes in schizophrenia
- Creators
- Ronald A. Yeo - University of New MexicoSteven W. Gangestad - University of New MexicoEsther Walton - Technische Universität DresdenStefan Ehrlich - Harvard UniversityJessica Pommy - University of New MexicoJessica A. Turner - Georgia State UniversityJingyu Liu - University of New MexicoAndrew R. Mayer - Mind Research NetworkS. Charles Schulz - University of MinnesotaBeng-Choon Ho - Roy J. and Lucille A. Carver College of MedicineJuan R. Bustillo - University of New MexicoThomas H. Wassink - Roy J. and Lucille A. Carver College of MedicineScott R. Sponheim - University of MinnesotaEric M. Morrow - Brown UniversityVince D. Calhoun - University of New Mexico
- Resource Type
- Journal article
- Publication Details
- Schizophrenia research, Vol.156(1), pp.71-75
- DOI
- 10.1016/j.schres.2014.03.022
- PMID
- 24768440
- PMCID
- PMC4699552
- NLM abbreviation
- Schizophr Res
- ISSN
- 0920-9964
- eISSN
- 1573-2509
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- P20RR021938 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) 5P20RR 021938; 1RC1MH089257; R01EB005846 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA RC1MH089257 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) DE-FG02-08ER64581 / U.S. Department of Energy; United States Department of Energy (DOE) R01EB005846 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984280835702771
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