Journal article
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Nature neuroscience, Vol.19(3), pp.420-+
03/01/2016
DOI: 10.1038/nn.4228
PMCID: PMC4852730
PMID: 26854805
Abstract
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
Details
- Title: Subtitle
- Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
- Creators
- Barbara Franke - Radboud University NijmegenJason L. Stein - University of Southern CaliforniaStephan Ripke - Broad InstituteVerneri Anttila - Broad InstituteDerrek P. Hibar - University of Southern CaliforniaKimm J. E. van Hulzen - Radboud University NijmegenAlejandro Arias-Vasquez - Radboud University NijmegenJordan W. Smoller - Harvard UniversityThomas E. Nichols - University of OxfordMichael C. Neale - Virginia Commonwealth UniversityAndrew M. McIntosh - University of EdinburghPhil Lee - Harvard UniversityFrancis J. McMahon - United States Department of Health and Human ServicesAndreas Meyer-Lindenberg - Central Institute of Mental HealthManuel Mattheisen - Aarhus UniversityOle A. Andreassen - University of OsloOliver Gruber - Center for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany.Perminder S. Sachdev - UNSW SydneyRoberto Roiz-Santianez - Universidad de CantabriaAndrew J. Saykin - Indiana UniversityStefan Ehrlich - Technische Universität DresdenKaren A. Mather - UNSW SydneyJessica A. Turner - University System of GeorgiaMargaret J. Wright - QIMR Berghofer Medical Research InstituteMichael C. O'Donovan - Cardiff UniversityPaul M. Thompson - University of Southern CaliforniaBenjamin M. Neale - Broad InstituteSarah E. Medland - QIMR Berghofer Medical Research InstitutePatrick F. Sullivan - Karolinska InstitutetENIGMA Consortium
- Contributors
- Beng Choon Ho (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- Nature neuroscience, Vol.19(3), pp.420-+
- DOI
- 10.1038/nn.4228
- PMID
- 26854805
- PMCID
- PMC4852730
- NLM abbreviation
- Nat Neurosci
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- R01HD050735 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) 01GS08144; 01GS08147; 01GS08148 / BMBF through the Integrated Genome Research Network MooDS under the National Genome Research Network plus (NGFNplus); Federal Ministry of Education & Research (BMBF) University Medical Center Groningen and Accare 01ZX1311A; 1EV0711 / BMBF (eMED SysAlc); Federal Ministry of Education & Research (BMBF) National Institute of Biomedical Imaging and Bioengineering; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) German Ministry of Cultural Affairs 313010 / FP7 grant NARSAD Stanley Medical Research Institute NSW Department of Health Genetic Association Information Network (GAIN) NIHR Biomedical Research Center MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Center for Brain Science Neuroinformatics Research Group 2013-123 / South-East Norway Health Authority William and Mary McIvor Endowment, Stanford University 911554 / HelseVest RHF University Medicine Greifswald RP-PG-0310-1002 / National Institute for Health Research programme grant 09-067048 / Danish Council for Strategic Research; Danske Strategiske Forskningsrad (DSF) NWO 480-05-003 / Netherlands Scientific Organization 525453 / NHMRC project grant; National Health and Medical Research Council of Australia 1045325; 310667; 401184; 525453; 568940; 389875; 486682; 1009064 / NHMRC; National Health and Medical Research Council of Australia Alzheimer's Australia Dementia Research Foundation Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL) 01GS08144; 01GS08147 / German Federal Ministry of Education and Research (BMBF) through the Integrated Genome Research Network MooDS under the National Genome Research Network plus (NGFNplus); Federal Ministry of Education & Research (BMBF) 076113/C/04/Z; 076113/CI04/Z; 072894/Z/03/Z; 090532/Z/09/Z; 075491/Z/04/B; 068545/Z/02 / Wellcome Trust; European Commission U01 AG024904 / Alzheimer's Disease Neuroimaging Initiative (ADNI) (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA County Council of Vasterbotten, Sweden Neuroscience Campus Amsterdam BCS-1229450 / National Science Foundation; National Science Foundation (NSF) Viertel Charitable Foundation Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under e:Med Programme (GlaxoSmithKline) G0800509 / UK Medical Research Council (MRC) Centre; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 602450; 602805; 278948 / European Community's Seventh Framework Programme (FP7); European Commission Ramsay Health Care Commonwealth Scientific and Industrial Research Organisation Flagship Collaboration Fund grant 01GS0481 / BMBF; Federal Ministry of Education & Research (BMBF) WTCCC-084710 / WTCCC2 grant MW904-61-193; MaGW-nr 400-07-080; MagW 480-04-004; 51.02.060; 668.772; NWO/SPI 56-464-14192 / NWO; Netherlands Organization for Scientific Research (NWO) Singapore Agency for Science, Technology and Research (A*STAR); Agency for Science Technology & Research (ASTAR) 016.130.669 / Vici grant from the NWO Hersenstichting Nederland 01ZZ9603; 01ZZ0103; 01ZZ0403 / BMBF (grants); Federal Ministry of Education & Research (BMBF) ERC-230374 / European Research Council; European Research Council (ERC); European Commission Max Planck Society; Foundation CELLEX Australian Government; CGIAR Walter E. Nichols, M. 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- Language
- English
- Date published
- 03/01/2016
- Academic Unit
- Psychiatry
- Record Identifier
- 9984280872402771
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