Journal article
Genetic insights into the in vivo functions of prostaglandin signaling
The international journal of biochemistry & cell biology, Vol.45(8), pp.1629-1632
08/2013
DOI: 10.1016/j.biocel.2013.05.008
PMID: 23685076
Abstract
Prostaglandins (PGs) are lipid signals that are produced at their sites of action by cyclooxygenase (COX) enzymes, the targets of non-steroidal anti-inflammatory drugs (NSAIDs), and PG-type specific synthases. Active PGs serve as ligands for G protein-coupled receptors (GPCRs). The functions of PGs have largely been elucidated using pharmacologic, expression-based (synthesis and signaling components), and genetic studies. In this review, we discuss the in vivo roles of PGs in cancer, development, and reproduction that have been characterized using genetic knockout/knockdown and overexpression approaches in mice, zebrafish, and invertebrate model systems, and how pharmacologic inhibition of PG synthesis affects cardiovascular health/disease and cancer incidence and progression.
Details
- Title: Subtitle
- Genetic insights into the in vivo functions of prostaglandin signaling
- Creators
- Tina L Tootle - Anatomy and Cell Biology Department, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- The international journal of biochemistry & cell biology, Vol.45(8), pp.1629-1632
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.biocel.2013.05.008
- PMID
- 23685076
- ISSN
- 1357-2725
- eISSN
- 1878-5875
- Language
- English
- Date published
- 08/2013
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025675502771
Metrics
21 Record Views