Journal article
Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers
Neurology, Vol.37(2), pp.325-329
1987
DOI: 10.1212/WNL.37.2.325
PMID: 3468376
Abstract
Hereditary motor and sensory neuropathy-Ib (HMSN-Ib) is a common autosomal dominant disorder linked to the Duffy blood group locus on human chromosome 1. The gene for antithrombin III (AT3) is also located on the long arm of chromosome 1. Using a DNA restriction fragment length polymorphism for AT3, we have investigated the genetic linkage relationship of all three markers (HMSN-Ib, Duffy, and AT3) in two affected families. Neither HMSN-Ib nor Duffy was tightly linked to AT3. The loci for both HMSN-Ib and Duffy must be close to the centromere on chromosome 1, but precise localization and gene order require study of additional markers and more families.
Details
- Title: Subtitle
- Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers
- Creators
- Phillip F Chance - Univ. Washington school medicine, dep. medicine, Seattle WA 98108, United StatesJeffrey C Murray - Univ. Washington school medicine, dep. medicine, Seattle WA 98108, United StatesThomas D Bird - Univ. Washington school medicine, dep. medicine, Seattle WA 98108, United StatesRochelle S Kochin - Univ. Washington school medicine, dep. medicine, Seattle WA 98108, United States
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.37(2), pp.325-329
- DOI
- 10.1212/WNL.37.2.325
- PMID
- 3468376
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Publisher
- Lippincott Williams & Wilkins; Hagerstown, MD
- Language
- English
- Date published
- 1987
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025566402771
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