Journal article
Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes
Genetic epidemiology, Vol.43(7), pp.844-863
08/13/2019
DOI: 10.1002/gepi.22242
PMID: 31407831
Abstract
Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
Details
- Title: Subtitle
- Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes
- Creators
- Lennox DinMohammad SheikhNikitha KosarajuKarin Ekström Smedby - Department of MedicineSasha Bernatsky - McGill University Health Center [Montreal]Sonja Berndt - National Cancer Institute [Bethesda]Christine Skibola - Emory University [Atlanta, GA]Alexandra Nieters - Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Freiburg, GermanySophia WangJames McKay - International Agency for Cancer ResearchPierluigi Cocco - Department of Public HealthMarc Maynadié - Registre des hémopathies malignes de Côte d'OrLenka Foretova - Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk UniversityAnthony Staines - GRAPHOS - IFROSS RechercheThomas MackSilvia SanjoséTimothy Vyse - Faculty of MedicineLeonid Padyukov - Karolinska Institutet [Stockholm]Alain Monnereau - Epidémiologie environnementale des cancersAlan ArslanAmy Moore - Department of Chemistry and Biochemistry [Boulder]Angela Brooks‐WilsonAnne NovakBengt Glimelius - Uppsala Universitet [Uppsala]Brenda BirmannBrian Link - Carver College of Medicine, University of IowaCarolyn StewartClaire VajdicCorinne Haioun - Service d'hématologie cliniqueCorrado MagnaniDavid ContiDavid Cox - Centre de Recherche en Cancérologie de LyonDelphine CasabonneDemetrius Albanes - Division of Cancer Epidemiology and GeneticsEleanor KaneEve Roman - Health SciencesGiacomo MuziGilles Salles - Service de Radio-Oncologie [Lyon]Graham Giles - University of MelbourneHans‐Olov AdamiHervé Ghesquieres - Centre Léon Bérard [Lyon]Immaculata VivoJacqueline Clavel - Epidémiologie environnementale des cancersJames Cerhan - Mayo Clinic [Rochester]John SpinelliJonathan Hofmann - Occupational and Environmental Epidemiology Branch [Bethesda, Maryland]Joseph Vijai - Memorial Sloane Kettering Cancer Center [New York]Karen Curtin - Huntsman Cancer InstituteKaren CostenbaderKenan OnelKenneth Offit - Clinical Genetics ServiceLauren TerasLindsay Morton - National Cancer Institute [Bethesda]Lucia CondeLucia Miligi - ISPO - Cancer Prevention and Research InstituteMads Melbye - Dept. of Epidemiology ResearchMaria Grazia Ennas - B.B. Brodie Department of NeuroscienceMark LiebowMark Purdue - National Cancer Institute [Bethesda]Martha Glenn - Huntsman Cancer InstituteMelissa Southey - Department of PathologyMorris DinNathaniel Rothman - National Cancer Institute [Bethesda]Nicola CampNicole Wong DooNikolaus Becker - Division of Cancer EpidemiologyNisha PradhanPaige BracciPaolo Boffetta - Unit of Environment Cancer EpidemiologyPaolo Vineis - University of Torino and CPO-PiemontePaul Brennan - International Agency for Cancer ResearchPeter Kraft - Department of EpidemiologyQing LanRichard Severson - Wayne State University [Detroit]Roel Vermeulen - Division of Environmental EpidemiologyRoger Milne - Cancer Epidemiology CentreRudolph KaaksRuth Travis - Cancer Epidemiology UnitStephanie WeinsteinStephen Chanock - Division of Cancer Epidemiology and GeneticsStephen Ansell - Mayo Clinic [Rochester]Susan Slager - Mayo Clinic [Rochester]Tongzhang ZhengYawei Zhang - De la Molécule aux Nanos-objets : Réactivité, Interactions et SpectroscopiesYolanda Benavente - Department of EpidemiologyZachary TaubLohith MadireddyPierre‐Antoine GourraudJorge Oksenberg - Department of Neurology [San Francisco, CA, USA]Wendy Cozen - Norris Comprehensive Cancer CenterHenrik HjalgrimPouya Khankhanian - Department of Neurology [San Francisco, CA, USA]
- Resource Type
- Journal article
- Publication Details
- Genetic epidemiology, Vol.43(7), pp.844-863
- DOI
- 10.1002/gepi.22242
- PMID
- 31407831
- NLM abbreviation
- Genet Epidemiol
- ISSN
- 0741-0395
- eISSN
- 1098-2272
- Publisher
- Wiley
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01CA134674, NO1‐CO‐12400; DOI: 10.13039/501100002794, name: Cancerfonden; DOI: 10.13039/501100000780, name: European Commission, award: QLK4‐CT‐2000‐00422, FOOD‐CT‐2006‐; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1 TR000135; DOI: 10.13039/100004440, name: Wellcome Trust, award: 085475/B/08/Z, 085475/Z/08/Z, 075491/Z/04/Z, and 068545/Z/02; DOI: 10.13039/501100006364, name: Institut National Du Cancer, award: P30 CA086862, P30 CA15083; DOI: 10.13039/501100005010, name: Associazione Italiana per la Ricerca sul Cancro, award: 11855; DOI: 10.13039/100007043, name: Lymphoma Foundation, award: LF5541; DOI: 10.13039/501100001809, name: National Natural Science Foundation of China, award: 61471078; DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: ES000260
- Language
- English
- Date published
- 08/13/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984071699202771
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