Journal article
Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants
Journal of perinatology, Vol.41(2), pp.286-294
02/2021
DOI: 10.1038/s41372-020-00821-w
PMCID: PMC7889697
PMID: 32978526
Abstract
To test associations between grades 3 or 4 (severe) intraventricular hemorrhage (IVH) and single nucleotide polymorphisms (SNPs) associated with coagulation, inflammation, angiogenesis, and organ development in an exploratory study.
Extremely low-birthweight (ELBW) infants enrolled in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's (NRN) Cytokines Study were included if they had cranial ultrasound (CUS) and genotyping data available in the NRN Anonymized DNA Repository and Database. Associations between SNPs and IVH severity were tested with multivariable logistic regression analysis.
One hundred thirty-nine infants with severe IVH and 687 infants with grade 1 or 0 IVH were included. One thousand two hundred seventy-nine SNPs were genotyped. Thirteen were preliminarily associated with severe IVH including five related to central nervous system (CNS) neuronal and neurovascular development.
Genetic variants for CNS neuronal and neurovascular development may be associated with severe IVH in premature infants.
Details
- Title: Subtitle
- Genetic predictors of severe intraventricular hemorrhage in extremely low-birthweight infants
- Creators
- Courtney D Thornburg - Duke UniversityStephen W Erickson - Social, Statistical and Environmental Sciences, RTI, Research Triangle Park, NC, USA.Grier P Page - University of UtahErin A S Clark - University of UtahMargaret M DeAngelis - University of UtahM Elizabeth Hartnett - University of KentuckyRicki F Goldstein - Duke UniversityJohn M Dagle - University of IowaJeffrey C Murray - University of IowaBrenda B Poindexter - University of CincinnatiAbhik Das - Rady Children's Hospital-San DiegoC Michael Cotten - Duke UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.41(2), pp.286-294
- DOI
- 10.1038/s41372-020-00821-w
- PMID
- 32978526
- PMCID
- PMC7889697
- NLM abbreviation
- J Perinatol
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Grant note
- UG1 HD040492 / NICHD NIH HHS U01 HG4423 / U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) U10 HD027871 / NICHD NIH HHS M01 RR008084 / NCRR NIH HHS U01 HG004423 / NHGRI NIH HHS M01 RR006022 / NCRR NIH HHS M01 RR016587 / NCRR NIH HHS U10 HD040498 / NICHD NIH HHS R01 HL105702 / NHLBI NIH HHS see below / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U10 HD021373 / NICHD NIH HHS U10 HD040492 / NICHD NIH HHS U10 HD021397 / NICHD NIH HHS U01 TR001792 / NCATS NIH HHS U10 HD040689 / NICHD NIH HHS U10 HD027904 / NICHD NIH HHS U10 HD053109 / NICHD NIH HHS U10 HD027856 / NICHD NIH HHS U10 HD027880 / NICHD NIH HHS U10 HD027853 / NICHD NIH HHS U10 HD021364 / NICHD NIH HHS U10 HD027851 / NICHD NIH HHS U10 HD034216 / NICHD NIH HHS R01 EY017011 / NEI NIH HHS U01 HD036790 / NICHD NIH HHS M01 RR007122 / NCRR NIH HHS see below / U.S. Department of Health & Human Services | National Institutes of Health (NIH) U10 HD021385 / NICHD NIH HHS U10 HD040461 / NICHD NIH HHS UL1 RR024979 / NCRR NIH HHS R01 EY015130 / NEI NIH HHS
- Language
- English
- Date published
- 02/2021
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Biochemistry and Molecular Biology; Dental Research; Neonatology
- Record Identifier
- 9984288726602771
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