Journal article
Genetic predisposition to obesity widens and skews the BMI distribution
Obesity research & clinical practice, Vol.12(4), pp.401-402
07/2018
DOI: 10.1016/j.orcp.2018.07.004
PMID: 30041858
Abstract
Genetic studies of BMI have largely focused on how average BMI changes with SNPs or polygenic risk scores (PRS). We examine the effects of a BMI PRS on changes in BMI percentiles, range, and skewness using quantile regression and US nationally representative data from the Health and Retirement Survey. We find that the BMI PRS is associated with meaningfully larger weight increases at higher than lower BMI percentiles; the 90th BMI percentile increases by 4.7 units with a one SD increase in the PRS compared to 1.5 units at the 10th percentile (both effects individually significant and significantly different from each other p≤0.0001). Our results suggest that PRS effects at average BMI mask substantial heterogeneity for individuals ranking at different BMI percentiles and that genetic effects are associated with greater spread and right skewness of the BMI distribution.
Details
- Title: Subtitle
- Genetic predisposition to obesity widens and skews the BMI distribution
- Creators
- George L Wehby - University of Iowa, Department of Health Management and Policy, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Obesity research & clinical practice, Vol.12(4), pp.401-402
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.orcp.2018.07.004
- PMID
- 30041858
- ISSN
- 1871-403X
- eISSN
- 1878-0318
- Language
- English
- Date published
- 07/2018
- Academic Unit
- Preventive and Community Dentistry; Health Management and Policy; Economics; Public Policy Center (Archive)
- Record Identifier
- 9984221639102771
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