Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan

Selma M B Jeronimo; Priya Duggal; Nicholas A Ettinger; Eliana T Nascimento; Gloria R Monteiro; Angela P Cabral; Nubia N Pontes; Henio G Lacerda; Paula V Queiroz; Carlos E M Gomes; Richard D Pearson; Jenefer M Blackwell; Terri H Beaty; Mary E Wilson

doi:10.1086/521682

Back

Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan

Journal article

Open access

Peer reviewed

Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan

Selma M B Jeronimo, Priya Duggal, Nicholas A Ettinger, Eliana T Nascimento, Gloria R Monteiro, Angela P Cabral, Nubia N Pontes, Henio G Lacerda, Paula V Queiroz, Carlos E M Gomes, …

The Journal of infectious diseases, Vol.196(8), pp.1261-1269

10/15/2007

DOI: 10.1086/521682

PMCID: PMC2330094

PMID: 17955446

Files and links (1)

url

https://doi.org/10.1086/521682View

Published (Version of record) Open Access

Abstract

The protozoan Leishmania chagasi can cause disseminated, fatal visceral leishmaniasis (VL) or asymptomatic infection in humans. We hypothesized that host genetic factors contribute to this variable response to infection. A family study was performed in neighborhoods of endemicity for L. chagasi near Natal in northeastern Brazil. Study subjects were assessed for the presence of VL or asymptomatic infection, which was defined by a positive delayed-type hypersensitivity (DTH) skin test response to Leishmania antigen without disease symptoms. A genomewide panel of 385 autosomal microsatellite markers in 1254 subjects from 191 families was analyzed to identify regions of linkage. Regions with potential linkage to the DTH response on chromosomes 15 and 19, as well as a novel region on chromosome 9 with potential linkage to VL, were identified. Understanding the genetic factors that determine whether an individual will develop symptomatic or asymptomatic infection with L. chagasi may identify proteins essential for immune protection against this parasitic disease and reveal strategies for immunotherapy or prevention.

Phenotype

Brazil

Chromosomes, Human, Pair 19 - parasitology

Hypersensitivity, Delayed - genetics

Leishmaniasis - immunology

Leishmaniasis - physiopathology

Humans

Immunity, Innate - genetics

Child, Preschool

Infant

Male

Chromosomes, Human, Pair 15 - genetics

Hypersensitivity, Delayed - immunology

Chromosomes, Human, Pair 15 - immunology

Endemic Diseases

Chromosomes, Human, Pair 19 - genetics

Chromosomes, Human, Pair 19 - immunology

Animals

Adolescent

Chromosomes, Human, Pair 15 - parasitology

Female

Leishmania - pathogenicity

Child

Genetic Linkage

Details

Title: Subtitle: Genetic predisposition to self-curing infection with the protozoan Leishmania chagasi: a genomewide scan
Creators: Selma M B Jeronimo - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, Natal, Rio de Grande do Norte, Brazil
Priya Duggal
Nicholas A Ettinger
Eliana T Nascimento
Gloria R Monteiro
Angela P Cabral
Nubia N Pontes
Henio G Lacerda
Paula V Queiroz
Carlos E M Gomes
Richard D Pearson
Jenefer M Blackwell
Terri H Beaty
Mary E Wilson
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.196(8), pp.1261-1269
Publisher: United States
DOI: 10.1086/521682
PMID: 17955446
PMCID: PMC2330094
ISSN: 0022-1899
eISSN: 1537-6613
Grant note: R01 AI045540 / NIAID NIH HHS AI048822 / NIAID NIH HHS Intramural NIH HHS T32 GM007337 / NIGMS NIH HHS AI45540 / NIAID NIH HHS R03 TW001369 / FIC NIH HHS AI30639 / NIAID NIH HHS R01 AI048822 / NIAID NIH HHS P50 AI030639 / NIAID NIH HHS 074196 / Wellcome Trust
Language: English
Date published: 10/15/2007
Academic Unit: Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
Record Identifier: 9984001140402771

Metrics

20 Record Views

46 Times Cited - Web of Science