Journal article
Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy
American journal of obstetrics and gynecology, Vol.199(2), pp.163.e1-163.e11
2008
DOI: 10.1016/j.ajog.2008.02.033
PMID: 18674658
Abstract
The purpose of this study was to evaluate the contribution of maternal genotype to the concentration of interleukin (IL)-4, −10, and −13 in the cervix during the first trimester in the context of bacterial vaginosis and cigarette smoking.
In this prospective cohort of 116 pregnant women, we examined 72 single nucleotide polymorphisms (SNPs) in 6 genes: IL-4, IL-4 receptor, IL-10, IL-10 receptor α, IL-10 receptor β, and IL-13.
Among black women, an IL-10 receptor β SNP (rs6517158) demonstrated significant association with IL-10 concentration (
P = .04), adjusted for bacterial vaginosis. Among white women, there were 4 SNPs in IL-10 receptor α with a highly significant association with IL-10 concentration, adjusted for bacterial vaginosis and smoking.
Our data demonstrate a significant relation between cervical concentrations of IL-10 and SNPs in the IL-10 receptor α and β genes. The contribution of genotype to IL-10 concentration is significant, even in the consideration of bacterial vaginosis and smoking.
Details
- Title: Subtitle
- Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy
- Creators
- Hyagriv N Simhan - Division of Maternal-Fetal Medicine and the Division of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PAKelli K Ryckman - Center for Human Genetics, Vanderbilt University School of Medicine, Nashville, TNScott M Williams - Center for Human Genetics, Vanderbilt University School of Medicine, Nashville, TNMarijane A Krohn - Division of Maternal-Fetal Medicine and the Division of Reproductive Infectious Diseases and Immunology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Research Institute, Pittsburgh, PA
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.199(2), pp.163.e1-163.e11
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.ajog.2008.02.033
- PMID
- 18674658
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Language
- English
- Date published
- 2008
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology
- Record Identifier
- 9983995103202771
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