Journal article
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Nature genetics, Vol.45(9), pp.984-994
08/28/2013
DOI: 10.1038/ng.2711
PMID: 23933821
Abstract
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Details
- Title: Subtitle
- Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
- Creators
- Hong Lee - Queensland Brain InstituteStephan Ripke - Stanley Center for Psychiatric ResearchBenjamin Neale - Analytic and Translational Genetics UnitStephen Faraone - Department of PsychiatryShaun Purcell - Stanley Center for Psychiatric ResearchRoy Perlis - Stanley Center for Psychiatric ResearchBryan Mowry - Queensland Brain InstituteAnita Thapar - Institute of Psychological Medicine and Clinical NeurosciencesMichael Goddard - Faculty of Land and EnvironmentJohn Witte - Department of Epidemiology and BiostatisticsDevin Absher - HudsonAlpha Institute for BiotechnologyIngrid Agartz - KG Jebsen Centre for Psychosis ResearchHuda Akil - Molecular Psychiatry LaboratoryFarooq Amin - Department of Psychiatry and Behavioral SciencesOle Andreassen - KG Jebsen Centre for Psychosis ResearchAdebayo Anjorin - Department of Psychiatry and Behavioral SciencesRichard Anney - Department of PsychiatryVerneri Anttila - Analytic and Translational Genetics UnitDan Arking - McKusick-Nathans Institute of Genetic MedicinePhilip Asherson - MRC Social, Genetic and Developmental Psychiatry CentreMaria Azevedo - Institute for Biomedical Imaging and Life ScienceLena Backlund - Department of PsychiatryJudith Badner - Department of PsychiatryAnthony Bailey - Department of PsychiatryTobias Banaschewski - Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim]Jack Barchas - Department of PsychiatryMichael Barnes - BioinformaticsThomas Barrett - Internal MedicineNicholas Bass - Mental Health Sciences UnitAgatino Battaglia - Department of PsychiatryMichael Bauer - Department of Psychiatry and PsychotherapyMònica Bayés - Centro Nacional de Análisis GenómicoFrank Bellivier - Institut Mondor de Recherche BiomédicaleSarah Bergen - Stanley Center for Psychiatric ResearchWade Berrettini - Department of Psychiatry [Philadelphia]Catalina Betancur - Physiopathologie des Maladies du Système Nerveux CentralThomas Bettecken - Center for Human Genetic ResearchJoseph Biederman - Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHDElisabeth Binder - Division Genetic Epidemiology in PsychiatryDonald Black - Department of PsychiatryDouglas Blackwood - Division of PsychiatryCinnamon Bloss - The Scripps Translational Science Institute and Scripps HealthMichael Boehnke - Department of Biostatistics and Center for Statistical GeneticsDorret Boomsma - Genetic Epidemiology UnitGerome Breen - MRC Social, Genetic and Developmental Psychiatry CentreRené Breuer - Department of Genetic Epidemiology in Psychiatry [Mannhein]Richard Bruggeman - Department of PsychiatryPaul Cormican - Department of PsychiatryNancy Buccola - School of NursingJan Buitelaar - Donders Center for Cognitive NeuroimagingWilliam Bunney - Department of Psychiatry and Human BehaviorJoseph Buxbaum - Friedman Brain Institute, Mount SinaiWilliam Byerley - Department of PsychiatryEnda Byrne - Queensland Brain InstituteSian Caesar - Department of Psychiatry, School of Clinical and Experimental MedicineWiepke Cahn - Department of PsychiatryRita Cantor - Department of Human Genetics, Los AngelesMiguel Casas - Department of PsychiatryAravinda Chakravarti - McKusick-Nathans Institute of Genetic MedicineKimberly Chambert - Stanley Center for Psychiatric ResearchKhalid Choudhury - Mental Health Sciences UnitSven Cichon - Department of Genomics, Life and Brain CenterRobert Cloninger - Department of PsychiatryDavid Collier - MRC Social, Genetic and Developmental Psychiatry CentreEdwin Cook - Department of Disability and Human DevelopmentHilary Coon - Department of Developmental NeuroscienceBru Cormand - Department of PsychiatryAiden Corvin - Department of PsychiatryWilliam Coryell - Department of PsychiatryDavid Craig - Department of PsychiatryIan Craig - MRC Social, Genetic and Developmental Psychiatry CentreJennifer Crosbie - Department of PsychiatryMichael Cuccaro - John P. Hussman Institute for Human GenomicsDavid Curtis - East London NHS Foundation TrustDarina Czamara - Max-Planck-Institut für PsychiatrieSusmita Datta - Genetics InstituteGeraldine Dawson - Autism Speaks and the Department of PsychiatryRichard Day - School of Neurology, Neurobiology and PsychiatryEco De Geus - Medstar Research InstituteFranziska Degenhardt - Department of Genomics, Life and Brain CenterSrdjan Djurovic - KG Jebsen Centre for Psychosis ResearchGary Donohoe - Department of PsychiatryAlysa Doyle - Psychiatric and Neurodevelopmental Genetics UnitJubao Duan - Department of Psychiatry and Behavioral SciencesFrank Dudbridge - Department of Non-Communicable Disease EpidemiologyEftichia Duketis - Department of Child and Adolescent Psychiatry, Psychosomatics and PsychotherapyRichard Ebstein - Psychology DepartmentHoward Edenberg - Department of Biochemistry and Molecular Biology, Department of Medical and Molecular GeneticsJosephine Elia - Department of PsychiatrySean Ennis - Academic Centre on Rare DiseasesBruno Etain - Institut Mondor de Recherche BiomédicaleAyman Fanous - Virginia Institute of Psychiatric and Behavioral GeneticsAnne Farmer - MRC Social, Genetic and Developmental Psychiatry CentreI Nicol Ferrier - University of Dundee School of MedicineMatthew Flickinger - Department of Biostatistics and Center for Statistical GeneticsEric Fombonne - Department of Child PsychiatryTatiana Foroud - Department of PsychiatryJosef Frank - Department of Psychiatry and Behavioral SciencesBarbara Franke - Department of Psychiatry and Behavioral SciencesChristine Fraser - Institute of Psychological Medicine and Clinical NeurosciencesCross-Disorder Group of the Psychiatric Genomics Consortium
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.45(9), pp.984-994
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/ng.2711
- PMID
- 23933821
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Language
- English
- Date published
- 08/28/2013
- Academic Unit
- Psychiatry
- Record Identifier
- 9984004083602771
Metrics
24 Record Views