Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics

Giorgio Sirugo; Branwen J Hennig; Adebowale A Adeyemo; Alice Matimba; Melanie J Newport; Muntaser E Ibrahim; Kelli K Ryckman; Alessandra Tacconelli; Renato Mariani-Costantini; Giuseppe Novelli; Himla Soodyall; Charles N Rotimi; Raj S Ramesar; Sarah A Tishkoff; Scott M Williams

doi:10.1007/s00439-008-0511-y

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Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics

Journal article

Peer reviewed

Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics

Giorgio Sirugo, Branwen J Hennig, Adebowale A Adeyemo, Alice Matimba, Melanie J Newport, Muntaser E Ibrahim, Kelli K Ryckman, Alessandra Tacconelli, Renato Mariani-Costantini, Giuseppe Novelli, …

Human genetics, Vol.123(6), pp.557-598

07/2008

DOI: 10.1007/s00439-008-0511-y

PMID: 18512079

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Abstract

Africa is the ultimate source of modern humans and as such harbors more genetic variation than any other continent. For this reason, studies of the patterns of genetic variation in African populations are crucial to understanding how genes affect phenotypic variation, including disease predisposition. In addition, the patterns of extant genetic variation in Africa are important for understanding how genetic variation affects infectious diseases that are a major problem in Africa, such as malaria, tuberculosis, schistosomiasis, and HIV/AIDS. Therefore, elucidating the role that genetic susceptibility to infectious diseases plays is critical to improving the health of people in Africa. It is also of note that recent and ongoing social and cultural changes in sub-Saharan Africa have increased the prevalence of non-communicable diseases that will also require genetic analyses to improve disease prevention and treatment. In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease.

Africa - epidemiology

Genetic Predisposition to Disease

Communicable Diseases - therapy

Genetic Testing

Communicable Diseases - epidemiology

Humans

Metabolic Diseases - epidemiology

Communicable Diseases - genetics

Immunotherapy, Active

Seroepidemiologic Studies

Metabolic Diseases - therapy

Neoplasms - therapy

Neoplasms - genetics

Metabolic Diseases - genetics

Polymorphism, Single Nucleotide

Genome, Human

Details

Title: Subtitle: Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics
Creators: Giorgio Sirugo - Medical Research Council Laboratories, Fajara, The Gambia, West Africa. sirugo.giorgio@fbfrm.it
Branwen J Hennig
Adebowale A Adeyemo
Alice Matimba
Melanie J Newport
Muntaser E Ibrahim
Kelli K Ryckman
Alessandra Tacconelli
Renato Mariani-Costantini
Giuseppe Novelli
Himla Soodyall
Charles N Rotimi
Raj S Ramesar
Sarah A Tishkoff
Scott M Williams
Resource Type: Journal article
Publication Details: Human genetics, Vol.123(6), pp.557-598
DOI: 10.1007/s00439-008-0511-y
PMID: 18512079
NLM abbreviation: Hum Genet
ISSN: 0340-6717
eISSN: 1432-1203
Publisher: Germany
Grant note: R01 HD041663 / NICHD NIH HHS
Language: English
Date published: 07/2008
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983996079902771

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